Insights on Ascletis' Innovative Treatments Being Presented

Exciting Developments from Ascletis Pharma

Ascletis Pharma Inc. (HKEX: 1672, "Ascletis") is making strides in the field of metabolic disease research. With its recent announcement, the company is set to present preliminary studies on its cutting-edge oral small molecule GLP-1 Receptor agonist ASC30 and the adipose-targeted weight loss drug candidate ASC47 at a prestigious event. The 85th Scientific Sessions of the American Diabetes Association (ADA) are highly regarded, providing a platform for showcasing groundbreaking research and innovations in diabetes treatment.

Poster Presentation Highlights

The upcoming poster presentations will feature two critical studies. The first, identified as Poster Number 750-P, will focus on ASC30. The abstract titled "ASC30, an Oral GLP-1R Biased Small Molecule Agonist in Participants with Obesity—A First-in-Human Single Ascending Dose Study," promises to provide key insights into the potential of this oral treatment for obesity.

Details on ASC30

ASC30 is particularly noteworthy as it represents an investigational treatment option possessing unique features that support its administration both as an oral tablet and via subcutaneous injection. This bi-modal delivery system provides flexibility for patient treatment plans and aids adherence. The benefits of ASC30 are reinforced by its status as a new chemical entity (NCE), protected by U.S. and global patents extending until 2044. This long patent life offers hope for ongoing research and development in the coming years.

The second study, listed as Poster Number 847-P, will present findings related to ASC47, a drug candidate aimed at addressing weight loss in obesity cases. The abstract titled "ASC47, a Muscle-Preserving Weight Loss Drug Candidate for Obesity, in Combination with Semaglutide, Demonstrated Superior Weight Loss to Semaglutide Monotherapy in a Preclinical Model" signifies a promising development in the management of obesity through drug synergy.

Focus on ASC47

ASC47 stands out due to its unique design as an adipose-targeted, ultra-long-acting small molecule agonist, which aims to enhance the treatment of obesity effectively. Developed in-house at Ascletis, ASC47 is designed to achieve higher concentrations of the drug in adipose tissue, which is essential for its weight loss efficacy. Preliminary results of its Phase Ib clinical trials conducted with participants having elevated low-density lipoprotein cholesterol (LDL-C) have been released, showing promising outcomes in terms of safety and efficacy.

The Importance of the ADA Conference

The American Diabetes Association, established in 1940, has been instrumental in diabetes advocacy. Its annual Scientific Sessions are a premier gathering for healthcare professionals, researchers, and industry leaders to share advancements and insights. This year's sessions, taking place in Chicago, provide an excellent opportunity for Ascletis to demonstrate the potential impact of its innovative drug candidates on the future of diabetes and obesity treatment.

Engagement and Future Outlook

Participation in a venue such as the ADA not only allows Ascletis to engage with the broader medical community but also offers the chance for collaborations that could further enhance its research initiatives. The company is committed to exploring new avenues in medical science and meeting the unfulfilled needs for effective obesity treatments, which remain a growing concern worldwide.

About Ascletis Pharma Inc.

Ascletis is dedicated to rigorous R&D, focusing on developing therapeutic solutions from the ground up. The company’s efforts span the full lifecycle of drug development, from the initial discovery phase through to GMP manufacturing. Supported by a highly experienced management team, Ascletis addresses unmet medical needs globally, particularly in the realm of metabolic diseases, and is continuously advancing its pipeline with multiple clinical-stage candidates.

Frequently Asked Questions

What is the significance of the ADA Scientific Sessions for Ascletis?

The ADA Scientific Sessions are crucial for Ascletis as they showcase its research on innovative treatments for obesity and diabetes, helping to influence clinical practice and research directions.

What are ASC30 and ASC47 focused on?

ASC30 is focused on obesity treatment through oral delivery, while ASC47 aims to provide a muscle-preserving weight loss option, demonstrating effectiveness when combined with existing therapies.

When will the presentations take place?

The presentations are scheduled during the ADA conference, specifically on June 22, promising to engage a diverse audience of diabetes researchers and clinicians.

What innovative approaches does Ascletis employ in its drug development?

Ascletis utilizes unique drug design strategies, such as dual administration routes for ASC30, to enhance patient compliance and treatment efficacy in metabolic diseases.

How does Ascletis plan to address global metabolic disease needs?

Ascletis aims to tackle unmet medical needs by continuously developing its drug candidates, backed by comprehensive research, to offer innovative solutions for obesity and diabetes management.

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