Innovative Trials at Hoag Family Cancer Institute to Fight Brain Cancer

Advancements in Glioblastoma Treatment at Hoag Family Cancer Institute

At the forefront of neuro-oncology innovation, the Hoag Family Cancer Institute is making significant strides in tackling glioblastoma (GBM), known as one of the most lethal forms of brain cancer. The institute, along with Hoag's Pickup Family Neurosciences Institute, has embarked on two promising clinical trials aimed at enhancing the diagnosis and treatment options for this challenging disease.

Focus of the LIBERATE Study and Its Impact

The LIBERATE study (NCT05383872) is a groundbreaking initiative sponsored by INSIGHTEC, focusing on the potential of Focused Ultrasound (FUS) to temporarily open the blood-brain barrier (BBB). This barrier is crucial in protecting the brain but can also hinder effective treatment options for GBM. By utilizing FUS to create a passage in the BBB, doctors can enable liquid biopsies through a simple blood test, moving away from more invasive surgical procedures.

Liquid biopsy represents an innovative method for collecting and analyzing vital biomarkers that guide diagnosis and treatment planning. One of the unique aspects of this study is that Hoag Family Cancer Institute is among a select group of just 17 sites across the nation participating in this trial. Dr. Simon Khagi, serving as the principal investigator, emphasizes the transformational potential of FUS technology.

Exploring Focused Ultrasound Technology

As a non-invasive treatment option, Focused Ultrasound harnesses the power of sound waves, guided by MRI imaging, to target deep tissue without needing incisions or radiation. The incorporation of this sophisticated technology at Hoag Family Cancer Institute has been made possible through the generosity of philanthropic contributions from local innovators dedicated to enhancing healthcare capabilities.

Expectations for Enhanced Treatment Outcomes

According to Dr. Khagi, "Focused Ultrasound has untold potential." The ability to open the BBB for a brief period allows for two pivotal actions: the extraction of fluids for biomarker testing and the infusion of targeted treatment directly into the brain. Most traditional therapies, such as chemotherapy and immunotherapy, struggle to reach brain tumors effectively. By using FUS to breach the BBB, new avenues for treatment delivery could significantly alter future clinical trials.

Delivering Enhanced Therapies through Collaboration

Hoag's commitment to innovation extends beyond glioblastoma treatments. The Pickup Family Neurosciences Institute is already successfully applying FUS technology for patients with essential tremors or Parkinson's disease. Dr. Christopher Duma highlighted the immediate results observed with this non-invasive procedure, showcasing the advantage of combining advanced technology with patient care.

Dr. Robert Louis, a leading figure in the institute, remarked on how Hoag's innovative spirit is fundamentally changing lives. The institution prioritizes offering advanced treatment options that may define the future of brain cancer therapies.

Researching Improved Immune System Therapies

In addition to the LIBERATE study, the Hoag Family Cancer Institute has been selected as one of two study sites for the QUILT 3.078 clinical trial. This trial explores the potential of N-803 and PD-L1 t-haNK cell therapy—promising agents for boosting the immune system—combined with Bevacizumab for recurrent or progressive glioblastoma. The study aims to ascertain the safety and efficacy of this combination, which involves both intravenous and subcutaneous delivery methods.

The institute is also actively investigating various immunotherapy options, particularly the use of NK cell therapy, which has shown promise across multiple cancer types. Dr. Khagi expressed pride in leading these innovative efforts, aiming to extend hope and enhance treatment prospects for glioblastoma patients.

Collaboration Among Experts for Best Outcomes

Looking ahead, the medical team at Hoag envisions a multi-modal approach to treating GBM, integrating therapies like FUS with cell therapy and devices like Optune Gio, which disrupts cancer cell division through electroporation. This comprehensive approach necessitates fearless collaboration among various specialists to tailor treatments that prioritize optimal patient outcomes.

Hoag’s Commitment to Patient-Centered Care

The unique care model at Hoag stands out as a blend of academic excellence and personalized healthcare, ensuring rapid adoption of pioneering trials for the local community. Hoag’s dedication to maintaining high standards of patient care is reflected in its philosophy, ensuring that individualized treatment plans are formulated based on detailed expertise.

For more details regarding the clinical trials available at Hoag Family Cancer Institute, interested parties can reach out directly via email or phone, ensuring they receive the latest information on cutting-edge cancer treatments.

Frequently Asked Questions

What is glioblastoma, and why is it significant?

Glioblastoma (GBM) is a type of brain tumor known for its aggressive nature and low survival rates, making effective treatment critical.

What is the LIBERATE study focusing on?

The LIBERATE study evaluates the use of Focused Ultrasound to facilitate liquid biopsies by temporarily opening the blood-brain barrier.

How does Focused Ultrasound work?

Focused Ultrasound uses sound waves to safely target brain tissue, allowing for enhanced treatment delivery without invasive procedures.

What are the potential benefits of participating in these trials?

Participants may gain access to innovative cancer therapies that are not widely available, with the potential for improved treatment outcomes.

How is Hoag Family Cancer Institute supporting innovation?

Through philanthropic efforts and a commitment to research, Hoag invests in advanced technologies and collaborates with experts to advance cancer treatment.

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