Innovative Partnership to Develop ALS Therapies with Lilly

Alchemab Therapeutics Collaborates with Lilly for ALS Research

Alchemab Therapeutics is embarking on an exciting collaboration with Lilly, aiming to advance the discovery and development of groundbreaking therapeutic options for amyotrophic lateral sclerosis (ALS). This partnership focuses on leveraging Alchemab's sophisticated antibody discovery platform, which is designed to identify and develop novel therapeutic antibodies, potentially revolutionizing ALS treatment.

Utilizing Unique Antibody Discovery Technology

At the heart of Alchemab's approach is the innovation in antibody discovery technology. By analyzing patient samples from individuals who experience slower than typical rates of disease progression, Alchemab seeks to uncover antibodies that are associated with resilience. These unique antibodies, often absent in those experiencing rapid disease progression, may offer novel therapeutic pathways.

Expanding Research with Robust Patient Samples

With access to a vast collection of ALS patient samples, Alchemab's collaboration with Lilly is set to harness its platform's capabilities to pinpoint antibodies that demonstrate resilience in ALS patients. This important work aims to push forward the most promising therapeutic candidates in the clinical development pipeline.

Insights from Alchemab's Leadership

Jane Osbourn, the Chief Executive Officer of Alchemab, expressed enthusiasm for the partnership, stating that their groundbreaking antibody discovery platform has the potential to reveal crucial insights into how the human immune response can create selective and unique antibodies with powerful therapeutic relevance. She highlighted the importance of this collaboration to address the pressing medical needs faced by ALS patients.

Goals of the Collaboration

The collaboration allows Alchemab to work closely with Lilly to discover, develop, and commercialize up to five innovative therapeutic options. As part of this agreement, Alchemab will receive an undisclosed upfront payment along with possible milestone payments and royalties that will aid in the furtherance of these valuable therapeutic discoveries.

Understanding ALS and Its Impact

Amyotrophic lateral sclerosis, commonly referred to as ALS, is a devastating neurodegenerative disease that does not currently have a known cure. Individuals affected by ALS often face increasingly debilitating symptoms that hinder their ability to speak, swallow, walk, and even breathe as motor neurons progressively deteriorate. The average life expectancy following the onset of ALS is alarmingly short, with many individuals living only two to four years. However, about 10% of patients do manage to survive longer than a decade.

About Alchemab Therapeutics

Alchemab is an innovative biopharmaceutical company founded in 2019, with a mission to identify therapeutic antibodies from resilient individuals. Their research emphasizes the importance of the natural immune response and aims to integrate data mining and machine learning with traditional drug discovery methods. By harnessing the lessons that resilient individuals teach us about disease, Alchemab seeks to develop treatment options for hard-to-treat diseases.

Funding and Growth

Since its inception, Alchemab has received substantial funding, exceeding $80 million from a prestigious group of investors, including SV Health Investors, DCVC Bio, and the Dementia Discovery Fund. This financial backing enables the company to continue its vital research and development efforts. Headquartered in London, UK, Alchemab operates research labs in Cambridge, UK, fostering an environment conducive to scientific discovery.

Frequently Asked Questions

What is the main goal of the collaboration between Alchemab and Lilly?

The main goal is to discover and develop novel therapeutic candidates for amyotrophic lateral sclerosis (ALS), leveraging Alchemab's antibody discovery technology.

How does Alchemab's technology support ALS research?

Alchemab's technology identifies antibodies from resilient individuals, which may provide new therapeutic targets for ALS patients, aiming to address significant unmet medical needs.

What impact does ALS have on individuals?

ALS is a terminal neurodegenerative disease that causes progressive loss of muscle function, leading to severe difficulties in daily activities and an average life expectancy of two to four years from onset.

What expertise does Jane Osbourn bring to Alchemab?

Jane Osbourn leads Alchemab with deep insights into immune responses and therapeutic development, showcasing commitment to tackling the challenges of ALS and similar diseases.

What does the future hold for Alchemab?

With ongoing collaborations, funding, and innovative research endeavors, Alchemab aims to play a pivotal role in advancing treatments that can significantly improve the quality of life for ALS patients and beyond.

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