Innovative iNKT Therapies Show Promise Against Advanced Cancers

MiNK Therapeutics Presents Groundbreaking Research

MiNK Therapeutics, Inc. (NASDAQ: INKT), a pioneering biopharmaceutical company focused on developing off-the-shelf invariant natural killer T (iNKT) cell therapies, is making significant strides in the battle against advanced gastroesophageal cancers. The company recently announced an important presentation at the American Society of Clinical Oncology Gastrointestinal Cancers (ASCO GI) Symposium, showcasing their innovative approach to cancer treatment.

A New Approach to Cancer Therapy

Dr. Jennifer Buell, CEO of MiNK Therapeutics, highlighted the critical role of iNKT cells in reshaping the immune landscape for patients suffering from complex cancers. Her remarks illuminate how the combination of Agenus' botensilimab and balstilimab (commonly referred to as BOT/BAL) enhances the immune system’s response by promoting T-cell activation and reducing regulatory cell suppression. This innovative combination fundamentally alters the tumor's environment, making it less hospitable for cancer to thrive.

Significant Clinical Trials Underway

Among the ongoing clinical trials, the Phase 2 study known as AgenT-797 plus BOT/BAL stands out. This trial, which is single-arm and investigator-initiated, evaluates the combination of iNKT cells, botensilimab, balstilimab, ramucirumab, and paclitaxel in patients with advanced gastroesophageal adenocarcinoma who have undergone prior treatments. This research is being conducted at the prestigious Memorial Sloan Kettering Cancer Center.

Promising Preliminary Results

Initial data from prior Phase I trials indicate that this multi-immune combination not only shows activity but also presents durable responses in patients who have previously failed PD-1 treatment. Specifically, notable benefits have been observed in gastric cancer patients, where robust T-cell infiltration and expansion were recorded in responders compared to non-responders.

Anticipation for Future Updates

MiNK Therapeutics is committed to transparency about its research advancements and plans to share further updates on these promising clinical results in the latter part of the year. The healthcare community eagerly awaits insights that could stem from this innovative research.

Details of the Presentation

The upcoming presentation at ASCO GI will feature crucial information regarding the study, including:

• Abstract Title: A phase II study of agenT-797 (iNKT cells), botensilimab, and balstilimab in advanced gastroesophageal adenocarcinoma.
• Presenting Author: Dr. Samuel Cytryn.
• Session: Trials in Progress Poster Session focused on gastrointestinal cancers.
• Date and Time: Scheduled for the specified session at ASCO GI.

Company Overview

MiNK Therapeutics is dedicated to creating transformative therapies through its promising pipeline of iNKT programs. The company is advancing both native and next-generation engineered programs, ensuring scalable and reproducible manufacturing to meet diverse patient needs. Based in New York, MiNK continues to prioritize innovations aimed at improving outcomes for patients battling immune-mediated diseases.

Frequently Asked Questions

What does MiNK Therapeutics focus on?

MiNK Therapeutics focuses on developing innovative iNKT cell therapies for treating cancer and other immune-mediated diseases.

What is the significance of the BOT/BAL combination?

This combination enhances T-cell activity and reprograms the immune system, improving responses against cancers.

What are the encouraging findings from the clinical trials?

The trials suggest that patients with PD-1 refractory cancers show durable responses and significant immune system improvement.

What can we expect from MiNK Therapeutics moving forward?

MiNK is expected to provide updates on its ongoing clinical trials and their effectiveness in treating advanced cancers.

How can investors get in touch with MiNK Therapeutics?

Investors can contact MiNK Therapeutics via their dedicated email address at investor@minktherapeutics.com for inquiries or additional information.

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