Innovative FIBRE Consortium Unites Leaders in Fibrosis Advances
Groundbreaking Launch of the FIBRE Consortium
Perceptive Discovery, a frontrunner in molecular and functional imaging research, has announced the formation of the FIBRE (Fibrosis Imaging Biomarker Research & Evaluation) Consortium. This innovative venture joins forces with leading industry players, including Pfizer, Lantheus, and Lumina Pharmaceuticals, with the aim of transforming the way multi-organ fibrotic diseases are treated. By harnessing advanced imaging techniques, the consortium seeks to drive the development of effective therapies that genuinely change patients' lives.
Addressing Unmet Medical Needs in Fibrosis
The FIBRE Consortium is focused on combating the increasing burden of fibrotic diseases, which present a significant and growing healthcare challenge. The collaboration is built upon the expertise of its members in drug development and pioneering imaging technology. Utilizing cutting-edge Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI), the consortium plans to identify and verify early biomarkers of disease. This approach is aimed at streamlining and enhancing the development of therapies that modify the course of these diseases.
Initial Studies and Targeted Research
The consortium's initial research will center on Metabolic Dysfunction-Associated Steatohepatitis (MASH), with the potential for further studies into various fibrotic conditions. By evaluating imaging tracers that target key proteins like Fibroblast Activation Protein (FAP) and Collagen Type I, they aim to uncover early indicators of disease progression. This research will take place at the Perceptive Discovery London Imaging Center, known for its high standards in data acquisition and imaging analysis.
Quote from Leadership
Eugenii A. Rabiner, the Executive Vice President and Global Head of Translational Applications at Perceptive Discovery, emphasized the urgent need for effective treatments for fibrotic diseases. “Fibrotic diseases are progressive and debilitating, and there is a critical demand for therapies that can truly modify their course. The application of molecular and functional imaging biomarkers allows us to enhance early-phase drug development, which may lead to reduced trial sizes and costs, ultimately increasing the likelihood of delivering promising therapies to patients in need.”
Collaboration and Data Sharing for Better Outcomes
The FIBRE Consortium aims not only to enhance therapeutic development but also to standardize care across various fibrotic diseases. By fostering collaboration among diverse sectors and promoting shared data, this initiative echoes the success of previous partnerships like MIND MAPS, which involved Perceptive Discovery, Pfizer, and other leading entities. Such collaborations are essential as they can attract additional biotech and pharmaceutical companies to join, each contributing to significant research insights and expertise.
Key Contributions of Partnering Companies
Lantheus, recognized for its dedication to innovative imaging solutions, will contribute a precursor for its PET imaging agent targeting FAP (LNTH-1363S) to the consortium. This agent will undergo radiolabeling with 18F, conducted by Perceptive, for use in clinical research within the FIBRE initiative. FAP serves as an important target because it is selectively found in activated fibroblasts that play a critical role in fibrosis progression.
Innovations from Lumina Pharmaceuticals
Lumina Pharmaceuticals will provide [??Ga]CBP8, a tracer designed to target Collagen Type I, which is crucial in pathological fibrosis. The PET imaging technology associated with [??Ga]CBP8 has demonstrated the ability to quantify pulmonary fibrosis and track collagen changes over time or in response to treatment. These contributions are vital in paving the way for future breakthroughs in fibrosis treatment.
Further Information and Partnership Opportunities
For organizations interested in learning more about the FIBRE Consortium or exploring partnership opportunities, the consortium extends an invitation to get in touch. This initiative represents a significant opportunity for collaboration that fosters extensive research and potentially game-changing advancements in the field of fibrosis.
Frequently Asked Questions
What is the FIBRE Consortium?
The FIBRE Consortium is a collaborative initiative founded by Perceptive Discovery, Pfizer, and other partners aimed at improving drug development for fibrotic diseases through advanced imaging biomarker research.
What diseases does the FIBRE Consortium focus on?
Initially, the consortium will focus on Metabolic Dysfunction-Associated Steatohepatitis (MASH) with prospects of extending research into other fibrotic diseases.
How will imaging technology be used in the consortium?
Imaging technology, specifically PET and MRI, will help identify and validate early disease biomarkers, which can streamline the development of therapies for fibrosis.
What companies are involved in the FIBRE Consortium?
Key partners include Perceptive Discovery, Pfizer, Lantheus, and Lumina Pharmaceuticals, all contributing their expertise and resources to the consortium's goals.
How can other organizations get involved?
Interests in partnership opportunities can be explored by contacting the consortium directly, as they are looking to attract additional biotech and pharmaceutical collaborators.
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