INmune Bio Showcases Promising XPro™ Results at Conference
INmune Bio Shares Exciting XPro™ Trial Results
INmune Bio Inc. (NASDAQ: INMB) recently announced significant insights from its Phase 2 MINDFuL trial, focusing on XPro™, a groundbreaking solitary TNF inhibitor. These findings will be discussed in an oral presentation at an upcoming Alzheimer’s Association International Conference. The session, which is eagerly anticipated by the Alzheimer’s research community, will take place in Toronto.
Understanding the MINDFuL Trial
The MINDFuL trial serves as a proof-of-concept study aimed at exploring XPro™’s effectiveness in slowing cognitive decline among individuals in the early stages of Alzheimer’s disease (AD). 208 participants, all with identifiable markers of neuroinflammation, joined the study. They received either XPro™ or a placebo over a 24-week period, with assessments conducted via the Early Mild Alzheimer’s Cognitive Composite (EMACC).
Trial Outcomes and Challenges
Although the primary outcome measures were not met across the entire participant cohort, the data revealed compelling benefits among a specific subgroup. Individuals confirmed to have amyloid-beta pathology combined with blood markers of systemic inflammation did show notable improvements in cognitive and behavioral assessments.
Expert Insights on XPro™
Dr. CJ Barnum, the Vice President of CNS Drug Development at INmune Bio, expressed optimism about the trial’s promising discoveries. He emphasized the key role of XPro™ in potentially addressing neuroinflammation in Alzheimer’s disease, suggesting it could offer essential benefits for both patients and their families.
Conference Presentation Details
Dr. Sharon Cohen, the principal investigator of the MINDFuL trial, will highlight these findings at the conference. As the medical director of the Toronto Memory Program, Dr. Cohen is excited to share these analytical results with stakeholders in the Alzheimer’s community, noting that targeting inflammation with XPro™ provides a unique and innovative therapeutic path.
Future Directions for XPro™
INmune Bio plans to submit a publication outlining the complete results of the MINDFuL study soon. The company also aims to pursue strategic collaborations to expedite the development of XPro™ as a viable treatment option for Alzheimer’s disease.
Gratitude to Contributors
The company extends its thanks to the participants, caregivers, and site staff who played critical roles in the success of the MINDFuL trial. Their support stands as a testament to the collaborative effort needed in exploring solutions for Alzheimer’s and related disorders.
About XPro™ and Its Mechanism
XPro™ is designed to selectively inhibit soluble TNF while preserving its role in trans-membrane forms. Through reducing neuroinflammation, XPro™ aims to improve conditions for patients with neurological disorders, potentially facilitating better cognitive functions and enhancing neuronal interactions.
About INmune Bio Inc.
INmune Bio Inc. is a clinical-stage biotechnology firm traded under NASDAQ: INMB, dedicated to advancing treatments that activate the innate immune system to combat various diseases. Their key technologies include the Dominant-Negative Tumor Necrosis Factor (DN-TNF) product platform, which specifically neutralizes soluble TNF implicated in numerous health conditions. The company is also engaged in developing methods to enhance natural killer cell responses in cancer patients.
Frequently Asked Questions
What is the purpose of the MINDFuL trial?
The MINDFuL trial investigates the efficacy of XPro™ in slowing cognitive decline in early Alzheimer’s patients by addressing neuroinflammation.
Who presented the findings at the Alzheimer’s Association International Conference?
Dr. Sharon Cohen, a neurologist and principal investigator, presented the findings, focusing on the trial's implications for Alzheimer's treatment.
What were the primary results of the MINDFuL trial?
While the primary endpoint was not achieved in the overall group, significant benefits were found in patients with confirmed amyloid-beta pathology and inflammation biomarkers.
How does XPro™ work?
XPro™ specifically inhibits soluble TNF, aiming to reduce neuroinflammation and potentially improve cognitive function in those affected by neurological disorders.
What is INmune Bio's vision for XPro™?
INmune Bio is focused on developing XPro™ as a treatment for Alzheimer’s disease, seeking partnerships to further expedite its development and realization in the market.
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