Harbour BioMed Partners with Windward Bio for Immunological Antibody

Harbour BioMed and Windward Bio Collaboration Details

Harbour BioMed, a global biopharmaceutical entity, has teamed up with Windward Bio AG to advance its innovative antibody therapy, HBM9378/SKB378. This partnership is part of Harbour BioMed's broader commitment to developing novel immunological treatments. HBM9378/SKB378 targets the thymic stromal lymphopoietin (TSLP), a crucial player in the immune response, showcasing significant potential for treating various immunological diseases.

Terms of the License Agreement

The collaboration granted Windward Bio an exclusive license for the research, development, manufacturing, and commercialization of HBM9378/SKB378 worldwide, excluding specific regions. This agreement includes financial incentives that could reach up to $970 million, comprised of upfront payments, milestone payments, and tiered royalties based on future sales. An immediate cash infusion of $45 million is part of this structure, highlighting the financial commitment to this promising collaboration.

Significance of the Partnership

Harbour BioMed views this partnership as a crucial step in harnessing the capabilities of Windward Bio for advancing HBM9378/SKB378. Dr. Jingsong Wang, the driving force behind Harbour BioMed, expressed enthusiasm for this alliance, seeing it as a pathway to leverage their advanced technology platform. The collaboration represents a strategic move to accelerate the development of breakthrough therapies that could drastically impact patient lives across the globe.

Insights into HBM9378/SKB378

HBM9378/SKB378, also known as WIN378, is a fully human monoclonal antibody designed using advanced technology. This project has been co-developed with Kelun-Biotech, ensuring both companies share the global rights in an equal manner. The antibody specifically targets TSLP, which influences various immunological disorders such as asthma and COPD. By blocking TSLP's interaction with its receptor, HBM9378/SKB378 can potentially interrupt disease progression and provide relief to patients.

Clinical Progress and Future Expectations

As part of its ongoing commitment to developing HBM9378/SKB378, Harbour BioMed has already submitted an Investigational New Drug (IND) application for this therapy in China. The company successfully completed a phase I clinical trial focusing on moderate-to-severe asthma, which bodes well for further clinical advancements. The immediate focus is on evaluating the therapy's safety and tolerability before progressing to later stages of clinical trials.

About Harbour BioMed

Harbour BioMed is dedicated to the discovery and development of pioneering antibody therapeutics in immunology and oncology fields. With its robust research and development initiatives, the company seeks to build a diverse portfolio of therapeutics. Notably, its proprietary Harbour Mice® platform stands out for generating fully human monoclonal antibodies, leading to significant advancements in therapeutic solutions.

Innovative Technology and Future Directions

The Harbour Mice® technology has transformed the landscape of antibody development, providing a unique format that enhances the potency and effectiveness of therapeutic antibodies. Furthermore, the company's development of HCAb-based immune cell engagers, known as HBICE®, exemplifies its innovative approach to tackling challenging medical problems, including targeting solid tumors through more effective treatment modalities.

About Windward Bio AG

Windward Bio is focused on addressing severe respiratory conditions and enhancing the quality of life for individuals facing advanced immunological challenges. Led by seasoned professionals with extensive experience in drug development, Windward Bio aims to leverage collaborations like the one with Harbour BioMed to bring promising treatments to the forefront of medical care.

Frequently Asked Questions

What is the primary focus of Harbour BioMed?

Harbour BioMed concentrates on discovering and developing innovative antibody therapeutics, particularly in immunology and oncology.

What does the license agreement with Windward Bio involve?

The license agreement allows Windward Bio to exclusively research, develop, manufacture, and commercialize HBM9378/SKB378 globally, excluding certain regions.

What potential financial benefits does Harbour BioMed anticipate?

Harbour BioMed could receive total payments of up to $970 million, including upfront payments, milestone payments, and royalties on sales related to HBM9378/SKB378.

What is HBM9378/SKB378 used for?

HBM9378/SKB378 is designed to target TSLP, potentially aiding in the treatment of various immunological conditions such as asthma and COPD.

What innovative platform does Harbour BioMed utilize?

Harbour BioMed employs its proprietary Harbour Mice® technology platform, which creates fully human monoclonal antibodies, enhancing therapeutic development capabilities.

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