HanchorBio Readies for Impact with New Oncology Data Releases
HanchorBio Gears Up for Major Oncology Presentations
Presentations highlight HCB101's unique profile and introduce first preclinical data from HCB301, underscoring HanchorBio's innovation in next-generation immunotherapies.
HanchorBio Inc. (TPEx: 7827), a prominent clinical-stage biotechnology company specializing in next-generation immunotherapies, has announced that it will present fresh clinical data from HCB101 and preclinical findings from HCB301 at five esteemed international oncology congresses this quarter.
This series of presentations aims to highlight advancements associated with HCB101, specifically the HCB101-101 monotherapy and the innovative HCB101-201 combination studies, in addition to the initial preclinical insights from HCB301. These developments underline the company's commitment to evolving immune checkpoint therapies that are at the forefront of cancer treatment.
Key Upcoming Oncology Congresses
The schedule for presentations at five major oncology conferences includes:
Federation of Asian Clinical Oncology
On October 24-25, 2025, HanchorBio will feature two poster presentations focusing on HCB101, detailing its efficacy both as a standalone treatment and in combination with standard care for advanced cancers.
Society for Immunotherapy of Cancer
From November 5-9, 2025, two late-breaking poster presentations will reveal essential findings from HCB101-101 and HCB101-201 studies, covering aspects of safety, pharmacology, and emerging efficacy. An additional presentation will introduce the first preclinical data from HCB301, showcasing HanchorBio's cutting-edge tri-specific fusion protein targeting multiple pathways.
ESMO Asia Congress
During the December 5-7, 2025 event, results from HCB101-101 will be updated, emphasizing its safety and effectiveness across various solid tumors and hematologic malignancies.
American Society of Hematology Annual Meeting
On December 6-9, 2025, a poster will detail the first-in-human Phase 1 study results for HCB101 focusing on patients with relapsed or refractory non-Hodgkin lymphoma.
ESMO Immuno-Oncology Congress
Finally, from December 10-12, 2025, an abstract will synthesize data from both HCB101 monotherapy and combination studies, reflecting its application across different solid tumor indications.
Scott Liu, Ph.D., Chairman, CEO, and Founder of HanchorBio, expressed enthusiasm about these presentations, stating, "The opportunity to present at five major oncology meetings underscores the extensive progress of HCB101's clinical journey. Our work continues to validate our unique approach to addressing CD47-SIRP? blockade, and the preliminary data from HCB301 exemplify the innovation from our FBDB™ platform in pursuing multi-checkpoint therapies. Collectively, they demonstrate our ongoing commitment to developing impactful treatments for patients battling difficult cancers and advancing next-generation immunotherapies."
Understanding HCB101's Differentiated Profile
HCB101 is a cutting-edge 3.5th-generation SIRP?-Fc fusion protein designed for efficient CD47 targeting while minimizing interactions that commonly lead to side effects like anemia or thrombocytopenia. This innovative approach preserves crucial mechanisms, such as antibody-dependent cellular phagocytosis (ADCP) and facilitation of innate to adaptive immune transfer.
Key Advantages of HCB101
- Enhanced Safety: It showcases a cytopenia-sparing profile with no significant toxicities at doses up to 24 mg/kg, achieving high receptor occupancy at lower dosages.
- Robust Immune Activation: With engineered features that promote ADCP and strengthen adaptive immunity, HCB101 reveals strong signals of sustained immune-mediated tumor control.
- Broad Tumor Applicability: Preclinical studies indicate effective outcomes in over 80 models, reflecting potential in various cancers including gastric, triple-negative breast, and ovarian cancers.
- Clinical Translation: It has shown promising results, including a notable partial response rate in combinations for specific cancer types, significantly surpassing historical performance.
Introducing HCB301: A Tri-Specific Approach
HCB301 is HanchorBio's innovative tri-specific immunotherapy that integrates multiple synergistic actions into one agent, facilitating CD47-SIRP? blockade, PD-1 inhibition, and suppression of the TGF-b pathway. Developed via the proprietary FBDB™ platform, this therapy is expected to enhance immune activity and exhibit powerful anti-tumor effects. Initial findings will be unveiled during the SITC 2025 event.
About HanchorBio
Headquartered in Taipei, Shanghai, and the San Francisco Bay Area, HanchorBio (7827.TPEx) is a forward-thinking biotechnology company centered on immuno-oncology. The company's leadership comprises experienced industry veterans with a history of successful biologics discovery and global development. HanchorBio's mission is to reactivate the immune system to combat diseases effectively. With the proprietary FBDB™ platform, HanchorBio crafts unique biologics designed to engage both innate and adaptive immunity, addressing the gaps present in current anti-PD1/L1 therapies. Their innovative approaches have yielded compelling proof-of-concept results across various preclinical models, paving the way for significant advancements in cancer therapies.
Frequently Asked Questions
What recent data is being presented by HanchorBio?
HanchorBio will present new clinical data on HCB101 and preclinical findings for HCB301 at five major oncology meetings.
What are the key benefits of HCB101?
HCB101 offers enhanced safety, robust immune activation, broad tumor applicability, and promising clinical results, making it a notable candidate for treating various cancers.
How does HCB301 differ from HCB101?
HCB301 integrates multiple mechanisms for cancer treatment, focusing on tri-specific immunotherapy compared to HCB101's focused CD47-SIRP? blockade.
Which congresses will HanchorBio attend for presentations?
HanchorBio will attend the Federation of Asian Clinical Oncology, Society for Immunotherapy of Cancer, ESMO Asia Congress, ASH Annual Meeting, and ESMO Immuno-Oncology Congress.
What is the primary goal of HanchorBio?
HanchorBio aims to innovate cancer therapies by reactivating the immune system and developing new immuno-oncology treatments using their proprietary platforms.
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