GENFIT Showcases Innovations in Liver Disease Research at AASLD
GENFIT Showcases Innovations in Liver Disease Research at AASLD
GENFIT, a renowned biopharmaceutical firm dedicated to addressing rare and severe liver diseases, is poised to make a significant impact at the upcoming American Association for the Study of Liver Diseases (AASLD) The Liver Meeting® 2025. This important event will be held in Washington, D.C., from November 7 to 11, and provides a platform for GENFIT to unveil groundbreaking data and insights from its extensive research pipeline.
Highlights from GENFIT's ACLF Pipeline
At the event, GENFIT will present critical findings that showcase the effectiveness of its programs in Acute on-Chronic Liver Failure (ACLF). Among the featured presentations will be:
Innovative Approaches in Nitazoxanide Reformulation
Poster #4165 will focus on the effects of G1090N, a reformulation of nitazoxanide. Titled Efficacy of nitazoxanide (NTZ) on systemic inflammation and organ function in disease models of Acute-on-Chronic Liver Failure when administered post-ACLF trigger, this study is anticipated to offer new insights into how NTZ can enhance patient outcomes in ACLF situations.
Inhibitory Effects of SRT-015
Another significant component is SRT-015 (Poster #4171), an ASK1 inhibitor demonstrating the ability to reduce systemic inflammation while enhancing immune function in ACLF-related models. These findings are crucial in understanding how to manage inflammation more effectively in ACLF patients.
Promising Research on CLM-022
Additionally, GENFIT’s poster #4565 will delve into the efficacy of CLM-022, which targets the NLRP3 inflammasome. This study reports on its effects in various disease models, potentially paving the way for new therapeutic strategies.
VS-01 Insights
Although the program for VS-01 in ACLF has been paused, promising preclinical studies in Urea Cycle Disorder (UCD) continue. These developments underscore GENFIT's commitment to exploring multiple avenues in liver disease therapeutics.
Real-World Evidence on ACLF Management
The AASLD meeting will also feature a session focused on real-world evidence (RWE) that highlights patient management disparities. One notable oral presentation, Oral presentation #0086, will illustrate significant differences in how patients admitted for acute decompensation are managed within hospital settings. This information is vital for improving patient care protocols.
Diagnostic and Prognostic Biomarkers
Another topical focus is on potential biomarkers. Presentation of Poster #2022 will discuss how circulating biomarkers such as sVCAM-1 and TSP2 are effective in predicting fibrosis progression toward cirrhosis, offering valuable tools for early detection and intervention.
Collaboration with Ipsen on Cholestatic Liver Diseases
Alongside its own presentations, GENFIT will highlight data presented by its partner, Ipsen, regarding Iqirvo® (elafibranor). This compound demonstrates remarkable potential in treating rare cholestatic liver diseases such as Primary Biliary Cholangitis (PBC) and Primary Sclerosing Cholangitis (PSC). Ipsen is set to present several abstracts from ongoing studies, underlining Iqirvo®’s efficacy in addressing symptoms and modifying disease progression.
Upcoming Events and Initiatives
To further support the liver health community, GENFIT has organized two important events during AASLD: the ACLF Insights event on November 7 and the ACLF Patient Advocacy Council on November 9. These gatherings aim to foster dialogue and collaboration among medical professionals, patients, and advocates.
About GENFIT
With over two decades of experience, GENFIT is at the forefront of research into liver diseases that significantly affect patients' lives. The company is currently focusing on enhancing the understanding and treatment of ACLF and related conditions. Its robust R&D portfolio includes innovative therapies and diagnostics designed to meet the urgent needs in this field.
In 2024, GENFIT achieved accelerated approval for Iqirvo® by prominent health authorities, marking a pivotal moment in its quest to improve treatment options for patients. This product is now available in various markets, solidifying GENFIT’s role as a leader in liver disease innovations.
Frequently Asked Questions
What is the focus of GENFIT's presentations at AASLD 2025?
GENFIT will present data on its ACLF pipeline, showcasing new research findings related to their innovative programs and partnerships.
How does G1090N contribute to ACLF treatment?
G1090N is expected to demonstrate efficacy in reducing systemic inflammation and improving organ function in ACLF patients.
What role do biomarkers play in GENFIT's research?
Biomarkers are crucial for identifying disease progression, allowing for earlier intervention and better outcomes for liver disease patients.
Who is collaborating with GENFIT on liver disease treatments?
GENFIT collaborates with Ipsen, focusing on the therapeutic potential of Iqirvo® in treating cholestatic liver diseases.
What future initiatives does GENFIT have planned?
GENFIT plans to hold events for the liver health community, including discussions on ACLF management and advocacy.
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