Enhancing Drug Discovery: IRBM's Strategic Genomics Expansion
IRBM Expands Its Functional Genomics Initiative
Empowering Innovators with Advanced Genetic Insights
IRBM, a leader in the realm of Contract Research Organizations specializing in preclinical drug discovery, has embarked on a major enhancement of its Functional Genomics Platform. This initiative aims to bolster the identification and validation of genetic targets and develop cellular models that are relevant to various diseases. By incorporating cutting-edge CRISPR methods, extensive screening capabilities, and proficient cell engineering, IRBM is well-equipped to facilitate target discovery and validation.
Innovative Tools for Target Validation
To significantly improve the processes of target validation, IRBM is enhancing its genome editing toolkit. This includes integrating CRISPR tiling, which systematically maps functional domains within coding and regulatory regions. Furthermore, the addition of base and prime editing enables precise nucleotide modifications. These advanced methodologies, coupled with the platform’s high-throughput CRISPR screening — which also encompasses stem cell engineering — are crucial for constructing reliable disease models and refining the validation of targets.
Understanding Viable Drug Development Targets
According to Dr. Sara Tomaselli, PhD, Head of Functional Genomics at IRBM, identifying which targets are genuinely viable for drug development is a multifaceted challenge. She asserts that the in-house platform fortifies their capability to systematically assess gene function, thereby de-risking early discovery stages and empowering their partners to make informed decisions.
Comprehensive Screening Capabilities
The scope of the platform encompasses genome-wide and targeted CRISPR libraries designed for knockout (CRISPR KO), inhibition (CRISPRi), and activation (CRISPRa). This allows for an in-depth exploration of gene functions and their associated pathways. In conjunction with IRBM’s expertise in cell engineering, which includes patient-relevant models and systems derived from induced pluripotent stem cells (iPSCs), a broad spectrum of disease modeling can be addressed — encompassing fields like oncology, neurodegeneration, and rare diseases.
The integration of multi-omics technologies, such as high-content imaging and single-cell transcriptomics, enables a profound functional characterization of potential drug targets. This interdisciplinary approach positions IRBM's Functional Genomics Platform as a cornerstone within a fully integrated drug discovery ecosystem. The ultimate goal is to ensure that genetic insights translate effectively into compelling preclinical models and strategic drug development plans.
Dr. Carlo Toniatti, MD, PhD, Chief Scientific Officer at IRBM, emphasizes a meticulous and methodical approach to functional genomics, which aligns seamlessly with the complexities involved in drug discovery. He aims to assist partners in uncovering high-quality targets and producing meaningful data that can guide and inform decision-making throughout the entire drug discovery continuum.
Collaborative Opportunities with Biotech Innovators
IRBM fosters a collaborative framework that empowers biotech startups, pharmaceutical companies, and venture-backed teams to tap into functional genomics expertise without the necessity for maintaining in-house infrastructure. By offering tailored solutions that range from genetic screening to engineered cell models and mechanistic studies, IRBM provides scientifically sound support at critical junctures within the drug development lifecycle.
Engagement with the Functional Genomics Community
For more information regarding IRBM's Functional Genomics Platform and collaboration possibilities, you can visit www.irbm.com.
About IRBM
IRBM is recognized as a contract research organization devoted to pioneering early-stage drug discovery. With a strong history of delivering preclinical candidates across various domains—including oncology, neurodegeneration, and infectious diseases—IRBM partners with biotech and pharmaceutical innovators to facilitate the advancement of therapeutic developments characterized by scientific precision and transparency.
Frequently Asked Questions
What is IRBM's main area of expertise?
IRBM specializes in preclinical drug discovery and functional genomics, helping partners identify viable drug targets.
How does the Functional Genomics Platform benefit drug discovery?
The platform enhances target identification, validation, and the development of disease-relevant cellular models, making drug discovery more efficient.
What technologies does IRBM utilize in its genomic research?
IRBM utilizes advanced CRISPR methodologies, multi-omics integration, and high-throughput screening to explore gene functions deeply.
Who can collaborate with IRBM?
Biotech startups, pharmaceutical companies, and venture-backed teams can leverage IRBM's expertise without needing in-house capabilities.
Where can I learn more about IRBM?
Further information about IRBM and its services can be found on their website at www.irbm.com.
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