Cognition Therapeutics Reveals EEG Insights from CT1812 Study
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Cognition Therapeutics Reveals EEG Insights from CT1812 Study
Cognition Therapeutics, Inc. (NASDAQ: CGTX), a clinical-stage company focused on developing innovative treatments for neurodegenerative disorders, has recently published significant findings from the SEQUEL study of CT1812, its lead drug candidate aimed towards Alzheimer’s disease therapy. These results have been reported in a prestigious journal, indicating advancements in understanding how CT1812 affects brain activity in adults with mild to moderate Alzheimer’s disease.
Overview of the SEQUEL Study
The SEQUEL study involved a single-site evaluation consisting of 16 adults diagnosed with mild to moderate Alzheimer’s disease. Participants received either daily doses of CT1812 or a placebo over a period of 29 days, with a focus on analyzing the brain's electrical activity through electroencephalography (EEG). The study aimed to assess the safety and efficacy of CT1812 while examining its impact on the brain's electrical impulses.
Key Findings from EEG Measurements
The findings from the SEQUEL study reveal that participants undergoing treatment with CT1812 demonstrated noticeable improvements across various EEG parameters. The most prominent of these were observed in the relative theta power in the central region of the brain, which displayed a statistically significant reduction (p=0.006), and changes in AEC-c* (p=0.034), a metric that evaluates inter-regional brain connectivity. These improvements suggest that CT1812 may play a role in normalizing brain wave patterns, which are typically disrupted in Alzheimer's disease.
Understanding Brain Connectivity Changes
Alzheimer's disease is often characterized by a gradual decline in brain connectivity and synaptic function, heavily impacting cognitive capabilities. The results from the SEQUEL study showed that treatment with CT1812 not only stabilized global relative theta power but also enhanced the alpha AEC-c measurements, indicating improved neural communication. This dual effect underscores CT1812’s potential neuroprotective benefits, suggesting that the medication may help restore vital synaptic activities.
Safety and Tolerability of CT1812
CT1812 has been demonstrated to be well tolerated among participants, with treatment-emergent adverse events (TEAEs) occurring at a mild to moderate level. Specifically, mild AEs were documented in 11 patients receiving CT1812 and in 6 patients taking the placebo, with no severe events leading to treatment discontinuation. This favorable safety profile strengthens the potential for CT1812 as a therapeutic option in Alzheimer’s treatment.
About CT1812: Mechanism of Action
CT1812 is an orally delivered small molecule that selectively binds to the sigma-2 (?-2) receptor complex, effectively blocking toxic A? oligomers from damaging neurons. The ?-2 receptor plays a critical role in maintaining cellular integrity, and by targeting it, CT1812 may reverse cellular damage sustained from Alzheimer’s pathology. Preclinical studies support the notion that this binding leads to improved synaptic function, creating hope for those affected by cognitive decline.
Future Directions and Studies
Ongoing clinical research includes the START and MAGNIFY studies, investigating CT1812’s effects in early Alzheimer’s disease and age-related macular degeneration, respectively. Furthermore, Cognition Therapeutics is poised to continue its investigational efforts into other neurodegenerative disorders, including dementia with Lewy bodies.
Contact Information
Cognition Therapeutics, Inc.
Email: info@cogrx.com
Media Contact: Casey McDonald
Tiberend Strategic Advisors, Inc.
Email: cmcdonald@tiberend.com
Investor Contact: Mike Moyer
LifeSci Advisors
Email: mmoyer@lifesciadvisors.com
Frequently Asked Questions
What is the SEQUEL study about?
The SEQUEL study evaluates the efficacy and safety of CT1812 in adults with mild to moderate Alzheimer’s by examining brain wave patterns through EEG.
What are the key findings from the SEQUEL study?
The study showed significant improvements in EEG parameters, particularly in brain connectivity and theta power, indicating potential neuroprotective effects of CT1812.
How well is CT1812 tolerated by patients?
CT1812 was well tolerated, with only mild and moderate treatment-emergent adverse events reported, and no serious complications occurred during the study.
What mechanism does CT1812 employ to combat Alzheimer’s?
CT1812 selectively binds to the sigma-2 receptor to displace toxic A? oligomers, potentially restoring synaptic function and improving cognitive performance.
Are there any ongoing studies involving CT1812?
Yes, Cognition Therapeutics is conducting the START and MAGNIFY studies to explore CT1812's effects in early Alzheimer’s disease and other conditions like age-related macular degeneration.
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