City Therapeutics Partners with Bausch + Lomb for Eye Health Advancements

City Therapeutics Forms Collaboration with Bausch + Lomb

In a groundbreaking move, City Therapeutics, Inc., a pioneering biopharmaceutical firm specializing in RNA interference (RNAi) medicine, has announced a strategic collaboration with Bausch + Lomb. This partnership aims to develop a novel treatment targeting retinal diseases, particularly geographic atrophy (GA), a severe form of age-related macular degeneration (AMD) that leads to vision loss.

Leveraging RNAi Technology

The partnership will allow City Therapeutics to utilize its advanced RNAi engineering technologies to create a new clinical candidate. This candidate will be designed for intravitreal administration, targeting a specific disease process associated with GA. If Bausch + Lomb commits to further development, they will lead the way in essential studies and regulatory processes.

Goals of the Collaboration

Andy Orth, the newly appointed CEO of City Therapeutics, expressed excitement over the partnership, emphasizing a shared vision with Bausch + Lomb to enhance RNAi-based therapies for patients facing significant unmet medical needs. The collaboration signals a major milestone for City Therapeutics, providing crucial funding to evolve their platform of innovative RNAi molecules targeted at broader ophthalmologic conditions.

Opportunities for Patients

Brent Saunders, chairman and CEO of Bausch + Lomb, highlighted the necessity for new solutions in the current GA treatment landscape, which has significant gaps. The collaboration aims to introduce an RNAi-based medicine that holds the potential for better patient outcomes and renewed hope for those affected by this debilitating condition. The collaboration is not just a commitment to innovation but also a dedication to addressing the needs of a large patient group.

Driving Innovation in Ophthalmology

John Maraganore, Ph.D., co-founder and executive chair of City Therapeutics, commented on the alignment of the partnership with Bausch + Lomb as a key player in ophthalmology. As a mutual strategy to enhance their pipeline through collaborations and proprietary programs, this venture illustrates their commitment to patient care and shareholder value.

Financial Structure of the Collaboration

The agreement establishes a financial framework where City Therapeutics will receive an upfront cash payment. If further development occurs, they could access substantial contingent payments, potentially reaching $485 million, based on milestone achievements in development, regulatory approvals, and sales. Additionally, City Therapeutics issued a convertible note to Bausch + Lomb, providing an avenue for a minority equity stake in the company upon conversion.

About City Therapeutics

City Therapeutics is at the forefront of the biopharmaceutical landscape, focusing on the advanced engineering of RNAi trigger molecules to broaden the scope of RNAi-based therapies. Co-founded by leaders in the RNAi field, City Therapeutics is committed to addressing health challenges across various therapeutic areas. With a well-established pipeline and financial backing totaling $135 million from prominent life sciences investors, City Therapeutics aims to make a significant impact on patient care.

Frequently Asked Questions

What is the purpose of the collaboration?

The purpose of the collaboration is to develop a novel RNAi-based therapy targeting geographic atrophy, aiming to provide better treatment options for affected patients.

What company is partnering with City Therapeutics?

Bausch + Lomb is the partner company, known for its expertise in eye health.

What are the potential financial benefits of this collaboration?

City Therapeutics could receive contingent payments totaling up to $485 million related to development and sales milestones, in addition to upfront payment.

What is geographic atrophy?

Geographic atrophy is a severe form of age-related macular degeneration that can lead to irreversible vision loss.

How does RNAi technology contribute to this treatment?

RNAi technology allows for precise targeting of specific disease processes, which can enhance therapeutic efficacy for conditions like geographic atrophy.

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