Catalyst Award Boosts Simmaron Research's Rapamycin Trial Efforts
Solve M.E. Honors Simmaron Research with Catalyst Award
Solve M.E. is thrilled to announce Simmaron Research as the recipient of the 2025 ME/CFS Catalyst Award. This esteemed award will provide crucial funding to propel their research in the study titled "Low Dose Rapamycin in ME/CFS, Long COVID, and Other Infection Associated Chronic Conditions (NCT06257420)." This innovative study is based on the hypothesis that inhibiting mTOR through rapamycin can mitigate issues related to autophagy impairment commonly observed in patients suffering from ME/CFS and other related conditions.
Innovative Research to Address ME/CFS and Long COVID Challenges
Solve M.E. is dedicated to ensuring that conditions like ME/CFS and Long COVID become well understood, easily diagnosable, and treatable. The organization invests in translational research aimed at converting biological discoveries into tangible therapeutic applications.
Simmaron Research stands at the forefront of this mission. As a dedicated research center, Simmaron focuses on developing first-of-its-kind animal models and identifying mechanisms that can vastly improve treatment options for patients. The team, led by Dr. C. Gunnar Gottschalk, includes renowned professionals like Dr. David Kaufman and Dr. Stephanie Grach from Mayo Clinic, contributing their expertise to drive this important work.
The Role of the Catalyst Award Fund
The Solve ME/CFS Catalyst Awards are strategically designed to support promising research endeavors, particularly amid the uncertainties of federal funding cycles. These awards facilitate studies in reaching crucial milestones—be it publication, clinical application, or other significant phases of investigation.
Emily Taylor, President and CEO of Solve M.E., expressed her enthusiasm about supporting this well-structured study: "We are delighted to back this ambitious project that builds on exciting biological insights. By utilizing an already FDA-approved medication, we aim to provide timely solutions to the ME/CFS community. Our Catalyst Award will allow Simmaron to enhance enrollment and acquire additional samples over a more extensive timeframe, fostering substantial progress towards effective care."
Previous Funding and Ongoing Research Advances
In a prior initiative, Solve M.E. awarded Dr. Avik Roy a Ramsay Research Grant, focusing on the relationship between ME/CFS symptoms and issues related to autophagy. With this grant, alongside NIH funding and support from private donors, the Simmaron team discovered that individuals with ME/CFS experience significant challenges with muscle-cell autophagy, which exacerbates post-exertional malaise.
Utilizing animal models, Simmaron has been investigating how autophagy and post-exertional malaise interrelate within the scope of ME/CFS, launching a multicenter clinical trial that explores the repurposing of rapamycin to alleviate symptoms such as fatigue and cognitive dysfunction. Their commitment to supporting these trials ensures continuous participant engagement and recruitment.
Hopeful Developments in Patient Care
A major advantage of the current study is its focus on tracking autophagy biomarkers, which could help predict which patients may benefit most from rapamycin treatments. Initial findings from nearly 80 participants have been encouraging, indicating that rapamycin reduces fatigue, sleep disturbances, and other debilitating symptoms.
Dr. Gottschalk elaborated, "The funding from Solve M.E. will be pivotal in continuing our expanded enrollment in collaboration with AgelessRx, as well as managing costs associated with the study drug and safety labs within this decentralized study. Our ultimate aim is to create a predictive test that identifies patients who are most likely to gain from rapamycin or other mTOR-targeted therapies."
A Legacy of Commitment to Research
Solve M.E. has a remarkable track record of funding ground-breaking research efforts directed at finding treatments for ME/CFS and related illnesses. Through its Ramsay Research Grant Program, the organization has supported close to 100 early-career researchers, yielding substantial returns and providing a foundation for more extensive funding initiatives.
The Catalyst Award program signifies Solve M.E.'s unwavering dedication to advancing scientific breakthroughs and enhancing research on ME/CFS and Long COVID. This initiative aims to inspire hope while aiming to make a meaningful impact on the lives of millions.
Frequently Asked Questions
What is the purpose of the Catalyst Award?
The Catalyst Award aims to support promising research in the field of ME/CFS and related conditions by providing essential funding.
Who received the Catalyst Award in 2025?
Simmaron Research was awarded the 2025 ME/CFS Catalyst Award for their study on Low-Dose Rapamycin.
What conditions are being studied with this Catalyst Award?
The study focuses on ME/CFS, Long COVID, and other infection-associated chronic conditions.
How does rapamycin relate to ME/CFS treatment?
Rapamycin may address issues of autophagy impairment seen in ME/CFS patients, potentially improving their symptoms.
What is Solve M.E.'s mission?
Solve M.E. seeks to facilitate understanding, diagnosis, and treatment of ME/CFS, Long COVID, and other related illnesses through research funding and advocacy.
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