C2N Diagnostics Collaborates with MJFF to Tackle Neurodegenerative Diseases

C2N Diagnostics Collaborates with MJFF to Tackle Neurodegenerative Diseases

In an exciting partnership, C2N Diagnostics is joining forces with The Michael J. Fox Foundation (MJFF) to investigate the complex relationships among several debilitating neurodegenerative conditions. These include Alzheimer’s disease (AD), Lewy Body Dementia (LBD), and Parkinson’s disease (PD). This collaboration aims to deepen our understanding of these diseases that significantly affect millions globally.

Understanding Neurodegenerative Conditions

Recent research highlights a gap in our knowledge regarding the prevalence of biomarkers associated with Alzheimer's disease and related dementias within the neuronal a-synuclein disease population. With a funding grant exceeding $1.5 million from MJFF, C2N intends to analyze fluid samples and novel biomarker test results to unravel how these diseases interact with one another.

Initial Phase of the Research Initiative

The first step in this collaborative effort involves leveraging the Parkinson's Progression Markers Initiative (PPMI) by MJFF. This initiative will utilize the innovative PrecivityAD2™ blood test developed by C2N. This test allows researchers to detect amyloid plaques in the brain, which are essential indicators of Alzheimer’s disease pathology.

Employing Advanced Biomarker Tests

In addition to the PrecivityAD2™ blood test, C2N will provide its proprietary biomarker test measuring the microtubule binding region of tau (MTBR-tau). This test holds significant promise for diagnosing and staging Alzheimer's disease. The research team will also focus on tracking how dementia and neurodegeneration biomarkers evolve over time, influencing the progression of neuronal a-synuclein disease.

Significance of the Collaboration

Dr. Samantha Hutten, who serves as Vice President of Translational Research at MJFF, emphasizes the importance of this partnership. “Since our inception in 2010, the PPMI has sought to identify valuable biomarkers of Parkinson’s disease,” she states. “By integrating C2N's validated biomarker tests with our established cohort of Parkinson's biosamples, we aim to propel research initiatives and clinical trials that can lead to effective treatments.”

Insights from C2N's Leadership

Dr. Joel Braunstein, the CEO of C2N Diagnostics, shares his enthusiasm for this collaboration with the Michael J. Fox Foundation. He notes, “Our partnership exemplifies how C2N harnesses its expertise in precision diagnostic tools aimed at Alzheimer’s disease and beyond.” He also underscores the utilization of advanced methodologies such as liquid-chromatography-tandem mass spectrometry (LC-MS/MS). This cutting-edge technology measures proteins in the blood that are crucial to the understanding of neurological disorders.

Ongoing Research and Contributions

C2N has played a pivotal role in the realm of neurological research, having contributed to more than 150 studies regarding Alzheimer’s disease and other related conditions. With their tests being critical in numerous clinical trials, they continue to strengthen collaborations with academic institutions, pharmaceutical companies, and leading organizations in the healthcare sector.

About C2N Diagnostics

C2N Diagnostics positions itself as a key player in specialty diagnostics, focusing on clarifying and advancing solutions for brain health. Their high-resolution mass spectrometry-based services are invaluable for clinical decision-making, improving patient care, and enhancing the quality and efficiency of clinical trials testing groundbreaking treatments for neurodegenerative diseases.

About The Michael J. Fox Foundation

The Michael J. Fox Foundation launched the PPMI in 2010 to enhance understanding of Parkinson’s disease and advance new therapeutic options. The initiative has transformed research methods and understanding, establishing a foundation for future clinical trials. With a goal to expand the participant base, the PPMI aims to enroll over 4,000 volunteers across the globe. The recently validated alpha-synuclein seed amplification assay, a crucial biomarker key to accelerating therapeutic development, exemplifies the foundation's influence in the field of Parkinson's research.

Frequently Asked Questions

What is the primary goal of the C2N and MJFF partnership?

The partnership aims to investigate the connections among Alzheimer’s disease, Lewy Body Dementia, and Parkinson's disease to improve understanding of these neurodegenerative conditions.

How much funding has MJFF provided to C2N Diagnostics?

MJFF has granted over $1.5 million to C2N for this research initiative aimed at studying neurodegenerative diseases.

What is the significance of the PrecivityAD2™ blood test?

The PrecivityAD2™ blood test is designed to detect amyloid plaques in the brain, which are critical indicators of Alzheimer's disease.

How many studies has C2N Diagnostics contributed to?

C2N Diagnostics has played a role in over 150 research studies that focus on Alzheimer’s disease and other related disorders.

What advancements has the PPMI initiative achieved?

The PPMI initiative has supported the discovery of key biomarkers and has influenced clinical trials, broadening the understanding of Parkinson’s disease.

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