Breakthrough Data for EO-1022 at AACR Highlights Oncology Innovation

Breakthrough Research Highlights EO-1022’s Potential

Elevation Oncology, Inc. (Nasdaq: ELEV), a pioneering company in the oncology sector, is making waves with new preclinical proof-of-concept data for their innovative HER3 antibody-drug conjugate (ADC), EO-1022. This ADC showcases exciting potential to meet significant unmet medical needs particularly in treating various solid tumors. The promising research findings will be presented during a late-breaking poster session at a distinguished annual oncology meeting.

Significant Preclinical Findings Displayed

Joseph Ferra, President and Chief Executive Officer of Elevation Oncology, expressed enthusiasm about the data presented for EO-1022. This ADC is crafted with several advanced features including glycan site-specific conjugation paired with MMAE payloads. Such innovations aim to enhance both efficacy and safety, ensuring better treatment outcomes for patients suffering from HER3-expressing cancers.

EO-1022: Robust Stability and Anti-Tumor Activity

The recent preclinical results indicate that EO-1022 boasts enhanced stability while demonstrating noteworthy anti-tumor activity compared to benchmark HER3 ADCs. This groundbreaking data, derived from both in vitro and in vivo models, highlights the efficacy of EO-1022 against various levels of HER3 expression. The advantages of these research outcomes are not limited to the laboratory; they also propose the possibility of reduced systemic toxicity in patients, thanks to the minimal exposure to free payload.

Standard Benchmarks and Comparisons

In the research presented, EO-1022 was shown to be highly stable in human serum, outperforming other ADCs that rely on stochastic conjugation methods. The reduction of free payload translates to a potentially safer profile for patients, setting EO-1022 apart from competing therapies.

Understanding the Science Behind EO-1022

EO-1022 is composed of seribantumab, a fully human IgG2 anti-HER3 monoclonal antibody. This ADC employs a focus on tailored treatment through site-specific conjugation with the MMAE payload, achieving a drug-to-antibody ratio (DAR) of 4. The design and development of EO-1022 utilize a sophisticated ADC platform licensed from Synaffix B.V., showcasing the company’s commitment to harnessing cutting-edge technology for cancer treatment evolution.

Pathway Forward: IND Application On the Horizon

With the anticipation of submitting an Investigational New Drug (IND) application for EO-1022 in the near future, Elevation Oncology is keen on addressing solid tumors that express HER3, spanning conditions such as breast cancer and non-small cell lung cancer. The future looks promising as they move forward with this advancement in cancer therapeutics.

Specialized Presentations and Data Insights

The poster titled "Preclinical discovery and characterization of EO-1022, a site-specific glycan-conjugated anti-HER3 vc-MMAE ADC for treating solid tumors," embodies critical data demonstrating EO-1022’s compelling attributes. Notable highlights include:

• Evidence of high stability and reduced free payload in serum, marking EO-1022 as a leader in its class.
• Potent cytotoxicity while depending on HER3 expression levels, showcasing adaptability in treatment.
• Prominent anti-tumor efficacy across various in vivo cancer models, including rare large patient-derived xenograft (PDX) models.

About EO-1022 and Its Impact

EO-1022 represents a significant step in the ongoing mission to enhance treatment for HER3-expressing solid tumors. Through the application of advanced ADC technology, the potential for transformative patient experiences is within reach. As Elevation Oncology continues to develop EO-1022, it not only aims to bring a robust therapeutic option but also seeks to address the widening gap in unmet medical needs across the oncology landscape.

About Elevation Oncology, Inc.

Elevation Oncology is dedicated to advancing the frontier of oncology through the discovery and development of selective cancer therapies. The expertise in antibody-drug conjugate technologies allows for a focused approach to tackling significant challenges associated with solid tumors. The company remains steadfast in its commitment to innovation, with EO-1022 paving the way for novel treatments.

Frequently Asked Questions

What is EO-1022?

EO-1022 is a HER3 antibody-drug conjugate designed for the treatment of solid tumors expressing HER3, promising improved efficacy and safety.

What are the main findings for EO-1022?

The findings reveal EO-1022 features enhanced stability, notable anti-tumor activity, and minimal toxicity due to reduced free payload levels.

When is the IND application expected?

Elevation Oncology anticipates filing the IND application for EO-1022 in 2026, looking towards clinical trials.

How does EO-1022 compare to other ADCs?

EO-1022 demonstrates superior stability and safety advantages over benchmark HER3 ADCs that utilize stochastic conjugation methods.

Where can I find more information about EO-1022?

For further information, keep an eye on Elevation Oncology’s updates regarding EO-1022 and its ongoing research efforts.

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