BioCryst Pharmaceuticals Reports Strong Revenue Growth for ORLADEYO

BioCryst Pharmaceuticals' Milestone Achievements in 2024

Recently, BioCryst Pharmaceuticals, Inc. (NASDAQ: BCRX) shared exciting news regarding their flagship product, ORLADEYO® (berotralstat). The company announced estimated net revenue of $437 million for the full year 2024, marking a significant 34 percent increase compared to the previous year. This growth reflects a strong demand and an impressive execution strategy over the past year.

Financial Overview and Future Projections

Looking ahead, BioCryst anticipates that ORLADEYO will continue to thrive, projecting net revenues between $515 million and $535 million in 2025. This anticipated growth underscores the effectiveness and acceptance of the therapeutic in the market.

Revenue Performance

In the fourth quarter of 2024 alone, ORLADEYO gained $123.5 million in revenue, a staggering 36 percent year-over-year growth. This remarkable performance led to an overall total revenue for 2024 of $450 million, representing a robust increase of 36 percent year-over-year.

Operational Growth and Profit Outlook

Jon Stonehouse, the President and CEO, expressed his enthusiasm, stating that 2024 was a pivotal year for the company. The operational profit achieved in 2024, excluding stock-based compensation, is a strong indicator of their path toward profitability. BioCryst expects to approach quarterly earnings per share (EPS) profitability by the second half of 2025, with a full-year projection of profitability for 2026.

Innovative Drug Development Plans

BioCryst is also expanding its offerings in the pediatric market, planning to submit a new drug application for ORLADEYO granules for children under 12 years old in 2025. This initiative addresses a critical unmet need and is anticipated to substantially enhance the company’s growth trajectory.

Advancing Clinical Pipeline

In addition to ORLADEYO, BioCryst is advancing its pipeline with two exciting therapies: BCX17725 for Netherton syndrome and avoralstat for diabetic macular edema, both expected to enter patient studies in 2025. Investing in these therapies signifies the company's commitment to treating rare diseases and expanding therapeutic options.

Financial Strategy and Future Investments

For the upcoming year, BioCryst predicts an operating expense range of $485 million to $495 million, including about $60 million attributed to stock-based compensation. This prudent financial strategy positions the company for sustained growth, especially as they ramp up investments for the launch of their pediatric product and ongoing clinical studies.

Challenges and Market Acceptance

Despite outstanding growth, BioCryst is navigating challenges inherent in the pharmaceutical industry. The company continues to enhance its commercialization strategies for ORLADEYO, focusing on market acceptance and a robust pipeline for future growth.

Engagement with Investors

On January 14, 2025, at the prestigious annual J.P. Morgan Healthcare Conference, BioCryst is set to present its strategic outlook and advancements in its therapeutic offerings. Investors and stakeholders are encouraged to follow the live audio webcast of the presentation to gain insights into BioCryst’s vision and business strategies.

About BioCryst Pharmaceuticals

BioCryst Pharmaceuticals is dedicated to improving the lives of individuals affected by rare diseases through innovative treatments. With ORLADEYO being the first oral plasma kallikrein inhibitor, its effectiveness is a testament to BioCryst's commitment to advancing drug development through advanced drug design techniques. To stay updated on their progress, you can visit their official website.

Frequently Asked Questions

What is the recent revenue for ORLADEYO?

The preliminary net revenue for ORLADEYO in 2024 was $437 million, reflecting a 34 percent growth year-over-year.

What are BioCryst's revenue projections for 2025?

BioCryst anticipates ORLADEYO's net revenue to range between $515 million and $535 million in 2025.

Is the company profitable?

While operational profit has been achieved in 2024, BioCryst expects to approach quarterly profitability in the second half of 2025 and aims for profitability in 2026.

What new developments can we expect from BioCryst?

BioCryst plans to submit a new drug application for ORLADEYO granules designed for pediatric patients, alongside advancing therapies for Netherton syndrome and diabetic macular edema.

How is BioCryst engaging with investors?

BioCryst will present at the annual J.P. Morgan Healthcare Conference, providing insights into its future strategies and developments.

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