Bexion Pharmaceuticals Secures Grant to Propel BXQ-350 Research

Bexion Pharmaceuticals Receives Michael J. Fox Foundation Grant

Bexion Pharmaceuticals, Inc., a dedicated clinical-stage biopharmaceutical company, has received a substantial grant to support its innovative research initiatives. This grant, awarded by The Michael J. Fox Foundation for Parkinson's Research, amounts to $1.4 million and will specifically fund the preclinical development of BXQ-350, Bexion's pioneering drug candidate aimed at treating Parkinson's disease.

Understanding BXQ-350

BXQ-350 is a unique biologic therapy that includes Saposin C, a multifunctional sphingolipid activator protein, which works in synergy with a phospholipid. This cutting-edge approach has shown promise in various Phase 1 trials, demonstrating not only a robust safety profile but also effectively targeting multiple types of solid tumors.

Competitive Edge in Treatment

Bexion’s research has highlighted BXQ-350 as an allosteric activator of glucocerebrosidase (GCase), an enzyme linked to genetic risk factors in Parkinson's disease. This is particularly significant as mutations in the GBA gene, responsible for producing GCase, pose the largest genetic risk for developing Parkinson's, affecting between 5% to 15% of patients. With this understanding, the potential impact of BXQ-350 is immense in providing new treatment options.

Jim Beach, the Chief Executive Officer of Bexion Pharmaceuticals, expressed gratitude for the grant and emphasized the company's commitment to exploring BXQ-350’s potential for neurodegenerative diseases. This initiative aligns with Bexion's mission to provide viable therapeutic avenues for patients who are currently underserved by existing solutions.

Collaborating for Change

Jessica Tome Garcia, PhD, from The Michael J. Fox Foundation, reaffirmed the foundation’s ongoing mission to fund innovative research that could revolutionize treatment methodology for Parkinson's disease. With BXQ-350 representing significant progress in fulfilling the urgent needs of patients, the collaboration between Bexion and MJFF highlights the importance of innovative approaches in biopharmaceutical research.

Current Research and Development Focus

Bexion is not just focused on the preclinical stages of BXQ-350. The company is currently conducting an open-label phase 1b/2 trial, where BXQ-350 is evaluated in combination with standard care for newly diagnosed metastatic colorectal cancer patients. Preliminary data has shown the drug's efficacy across various solid tumor types, and there’s also potential to treat chemotherapy-induced peripheral neuropathy (CIPN), particularly in patients who have undergone treatment involving oxaliplatin.

A Commitment to Advancing Therapy

Bexion Pharmaceuticals holds a promising position in the biopharmaceutical landscape, as the company continues to explore new territories in drug development. With plans to extend beyond solid tumors and delve into broader neuropathic pain therapies, Bexion is determined to address significant unmet medical needs. They have established a positive track record in developing potential treatments for diverse oncological conditions, including pediatric brain tumors and high-grade gliomas.

Investor Relations and Media Contact Information

For investors or media inquiries, Bexion Pharmaceuticals has provided contact details for further information. William Windham of Solebury Strategic Communications is available for investor communications, while Joyce LaViscount represents media inquiries for the company. Their aim is to ensure that interested parties remain informed about Bexion’s advancements and strategic initiatives.

Frequently Asked Questions

What is BXQ-350?

BXQ-350 is Bexion Pharmaceuticals' investigational biologic therapy aimed at treating solid tumors and chemotherapy-induced peripheral neuropathy.

How much funding did Bexion receive?

Bexion Pharmaceuticals was awarded a grant of $1.4 million from The Michael J. Fox Foundation to advance its research in BXQ-350.

Why is the GCase enzyme significant?

The GCase enzyme's significance lies in its link to genetic risk factors for Parkinson's disease, affecting a notable percent of the patient population.

What tumors is BXQ-350 being tested on?

BXQ-350 is currently being tested on various solid tumor types through ongoing clinical trials.

Who can I contact for more information about Bexion?

You can contact William Windham for investor inquiries and Joyce LaViscount for media inquiries at Bexion Pharmaceuticals.

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