ALX Oncology Reports Strong Outcomes in B-cell Lymphoma Trials
Promising Results from ALX Oncology's Phase 1 Clinical Trial
ALX Oncology Holdings Inc. (Nasdaq: ALXO), a pioneering clinical-stage biotechnology company, has shared encouraging outcomes from its Phase 1 trial exploring the combination of evorpacept, an innovative CD47-blocker, alongside established treatments, rituximab and lenalidomide (commonly called R2). Data slated for presentation at the upcoming AACR Annual Meeting in 2025 indicates that this novel therapy combination not only proved to be well-tolerated but also showcased notable anti-tumor activities.
Outstanding Response Rates in Clinical Trial
The combined approach demonstrated an impressive complete response (CR) in 83% of patients battling indolent relapsed or refractory B-cell non-Hodgkin lymphoma (B-NHL). This performance significantly outshines the historical CR rate of 34% associated with R2 therapy alone, highlighting the potential of evorpacept in enhancing treatment outcomes.
Long-term Survival Prospects Encouraging
After a median observation period of 28 months, the trial results unveiled a two-year progression-free survival (PFS) rate of 69% and an overall survival (OS) rate of 84%. These statistics indicate a strong therapeutic impact on the enrolled patients, especially those who had previously struggled with their conditions. Of the 20 participants, 80% were found to achieve a complete response overall, further underscoring the efficacy of this combination treatment.
Leader's Insight on Enhanced Treatment Potential
Dr. Paolo Strati, who helms the trial and serves as an Associate Professor at The University of Texas MD Anderson Cancer Center, noted, “Evorpacept is crafted to activate the innate immune response, targeting macrophage activity to amplify the treatment benefits of established anti-cancer agents like rituximab.” His insights emphasize the possibility that this synergistic approach may resolve resistance to prior therapies, thereby leading to improved outcomes.
Ongoing Developments in Clinical Trials
As the trial progresses, investigators have begun a Phase 2 segment catering to patients with previously untreated indolent NHL, marking an important evolution in this research. ALX Oncology is committed to continuing the investigation of evorpacept to ascertain its full therapeutic potential.
Details of the Upcoming Presentation
Specifics regarding the poster presentation at the AACR 2025 conference include:
- Title: Final results of a phase I trial of evorpacept (ALX148), lenalidomide, and rituximab for patients with B-cell non-Hodgkin lymphoma
- Presenter: Dr. Paolo Strati
- Session Title: Late-Breaking Research: Clinical Research 3
- Date/Time: April 29, 2025, from 2:00 PM to 5:00 PM CT
- Location: McCormick Place Convention Center, Poster Section 53, Board Number: 13
- Published Abstract Number: LB369
A comprehensive copy of the AACR 2025 presentation will be available on the ALX Oncology website post-event.
About ALX Oncology: A Leader in Cancer Treatment
This innovative biotechnology company is at the forefront of advancing transformative therapies aimed at tackling cancer and enhancing quality of life for patients. With its lead candidate, evorpacept, ALX Oncology reinforces its ambition to reshape immuno-oncology treatments and demonstrate clinical efficacy across various cancer indications.
Frequently Asked Questions
What is the main focus of the trial conducted by ALX Oncology?
The trial primarily evaluates evorpacept combined with standard treatments for B-cell non-Hodgkin lymphoma, aiming to enhance patient responses.
What were the major findings in the Phase 1 trial?
The trial showcased a complete response rate of 83% among treated patients, significantly exceeding historical rates.
Who presented the findings of the trial?
The findings will be presented by Dr. Paolo Strati, an esteemed expert in lymphoma treatment.
What does the ongoing Phase 2 portion of the trial aim for?
The Phase 2 portion is exploring the effectiveness of evorpacept in patients with previously untreated indolent NHL.
Where can I find more information about ALX Oncology?
Additional details about the company and its innovative pipeline can be accessed through their official website.
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