Alterity Therapeutics Prepares Key Presentations on ATH434

Alterity Therapeutics' Upcoming Presentations

Alterity Therapeutics Limited (ASX: ATH, NASDAQ: ATHE) is making significant strides in the fight against neurodegenerative diseases. As a clinical-stage biotechnology company, Alterity is dedicated to discovering innovative treatments that address the challenges posed by conditions like Multiple System Atrophy (MSA). At the upcoming International Congress of Parkinson's Disease and Movement Disorders, Alterity will present critical data from the ATH434-201 trial.

Understanding the ATH434-201 Clinical Trial

The ATH434-201 trial is a randomized, double-blind, placebo-controlled study that evaluates the effects of ATH434 over a 12-month period in patients with MSA. This trial includes comprehensive assessments of efficacy, safety, and pharmacokinetics, utilizing advanced neuroimaging techniques and wearable sensors to monitor participants' motor activities outside clinical settings.

Key Findings from the Trial

Initial results have indicated that patients taking ATH434 experience clinically and statistically significant improvements on the modified Unified Multiple System Atrophy Rating Scale (UMSARS) Part I. This improvement shows promise in enhancing daily activities affected by MSA. The trial highlights ATH434's potential to reduce iron accumulation in critical brain regions, a key factor in neurodegeneration.

Details of the Presentations

At the congress, Alterity will not only present their oral platform session but also engage attendees with multiple poster presentations. This is an opportunity for the company to provide insights into their innovative approach to treating MSA, sharing findings with global leaders in the field. David Stamler, M.D., CEO of Alterity, will lead the pivotal oral presentation discussing ATH434’s ability to slow disease progression.

Presentation Schedule

During the event, the oral presentation titled "ATH434 Slowed Disease Progression in a Phase 2 Study in Multiple System Atrophy" is scheduled for October 8, where Dr. Stamler will unveil the key outcomes of the trial. Additional poster presentations will shed light on the interplay between ?-synuclein aggregation profiles and disease severity.

Further Aspects of ATH434

ATH434 operates as an iron chaperone and is designed to halt the aggregation of proteins that lead to neurodegenerative diseases. Preclinical studies have shown its effectiveness in preserving neuronal function, giving hope for its application in treating Parkinson's disease and MSA. The favorable safety profile established during early-phase trials suggests a strong potential for future therapeutic use.

Recent Clinical Developments

In noteworthy development, the FDA has recognized ATH434’s potential by granting it Fast Track Designation, as well as Orphan Drug Designation for treating MSA. This regulatory support underscores the drug’s promise and Alterity’s commitment to advancing treatment options for patients afflicted with this serious condition.

The Challenge of Multiple System Atrophy

MSA is a rare and rapidly progressive neurodegenerative disease that severely impacts autonomic functions and motor abilities. With symptoms including muscle rigidity, impaired movement, and autonomic instability, it poses significant challenges and currently lacks effective treatments aimed at slowing its progression. The urgency for innovative therapies cannot be overstated, as MSA affects thousands of individuals.

Alterity's Mission

Alterity Therapeutics stands at the forefront of biotechnological innovation, aiming to create a brighter future for those living with neurodegenerative diseases. With ongoing research and development, the company continues to explore avenues for potentially life-altering treatments while expanding its portfolio of drug candidates.

Frequently Asked Questions

What is ATH434?

ATH434 is an oral treatment developed by Alterity Therapeutics designed to prevent the aggregation of proteins linked to neurodegeneration, particularly in conditions like MSA.

When will the presentations take place?

Alterity will present the findings from their ATH434-201 clinical trial on October 8, during the International Congress of Parkinson's Disease and Movement Disorders.

What results were seen in the Phase 2 trial?

The Phase 2 trial indicated ATH434 significantly improves functionality in daily activities for those suffering from MSA as demonstrated by scores on the UMSARS.

What designations has ATH434 received?

ATH434 has been granted Fast Track Designation and Orphan Drug Designation by the FDA for its use in treating MSA.

How is Alterity Therapeutics contributing to neuroscience?

Alterity Therapeutics is dedicated to developing novel therapies that can alter disease progression in neurodegenerative conditions, focusing on innovative clinical trials and comprehensive research.

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