Advancements in ICAM-1 CAR T Therapy Showcased at AACR 2025
AffyImmune Announces Key Developments in CAR T Therapy
AffyImmune Therapeutics, Inc., a pioneering clinical-stage biopharmaceutical company, is making waves with its latest announcement about the affinity-tuned CAR T therapy, AIC100. This innovative treatment will be showcased at the prestigious American Association for Cancer Research (AACR) Annual Meeting. The event is scheduled to take place at McCormick Place Convention Center, and AffyImmune’s presentation is eagerly anticipated by industry experts and attendees alike.
Presentation Overview and Key Insights
The focus of the presentation will be the updated Phase 1 data from their ongoing Dose Escalation trial. This trial evaluates AIC100 CAR T therapy specifically in patients suffering from advanced thyroid cancers. Daniel Janse, the CEO of AffyImmune, expressed excitement about sharing these interim safety and efficacy results. Janse highlighted that this presentation marks a pivotal moment in advancing their therapies that address significant unmet medical needs.
Presentation Details
The details regarding the presentation are as follows:
- Title: ICAM-1 directed chimeric antigen receptor (CAR) T cells (AIC100) in patients with Advanced Thyroid cancers: Clinical and translational data from the phase 1 dose escalation study
- Presenter: Dr. Samer Ali Srour from the University of Texas MD Anderson Cancer Center
- Session Type: Oral Presentation – Clinical Trials Plenary Session
- Abstract Number: CT206
- Date and Time: April 29, 2025, from 10:15 AM to 12:15 PM CST
Innovative Approaches in Cancer Therapy
AffyImmune's approach leverages their distinctive proprietary technology that enhances the ICAM-1/LFA-1 interaction. This advancement is expected to tackle common CAR T challenges, such as toxicity, antigen loss, and T-cell exhaustion. AIC100 represents a significant step forward not only in targeting advanced thyroid cancer but also in the potential for in vivo tracking of CAR T cells, enhancing treatment precision and patient safety.
About AffyImmune Therapeutics
AffyImmune is on a mission to transform the landscape of cancer treatment through pioneering therapies designed to meet pressing healthcare challenges. The company is specifically focused on developing first-in-class CAR T cell therapies, with AIC100 as their flagship candidate targeting advanced thyroid cancer patients. Their ongoing commitment is evident in their rigorous development pipeline aimed at addressing various oncologic indications.
Future Directions for AffyImmune
As the company continues its development of CAR T therapies, it maintains a relentless focus on patients with high unmet medical needs. The upcoming presentation at AACR 2025 will serve as a powerful platform for sharing their findings and discussing next steps in therapeutic advancements aimed at helping individuals facing challenging cancers.
Frequently Asked Questions
What is AffyImmune Therapeutics focused on?
AffyImmune Therapeutics is dedicated to developing novel CAR T cell therapies to treat patients with various cancers.
What is AIC100?
AIC100 is an ICAM-1 directed CAR T therapy being developed for treating patients with advanced thyroid cancer.
When is AffyImmune presenting at AACR?
The presentation is scheduled for April 29, 2025, during the Clinical Trials Plenary Session.
Who will present the AIC100 data?
Dr. Samer Ali Srour from the University of Texas MD Anderson Cancer Center will be the presenter.
How does AIC100 enhance CAR T therapy?
AIC100 utilizes an innovative ICAM-1/LFA-1 interaction to reduce challenges such as toxicity and T-cell exhaustion.
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