Adagene Showcases Promising Results for ADG126 in Cancer Trials
Exploring the Latest ADG126 Combinations in Colorectal Cancer
Adagene Inc. (Nasdaq: ADAG), renowned for innovating in the field of antibody-based therapies, has revealed encouraging new data regarding its investigational treatment ADG126, also known as muzastotug. Presenting at the prestigious American Society of Clinical Oncology (ASCO) Annual Meeting, the company outlined findings from its Phase 1b/2 study, which highlights the effectiveness of ADG126 when combined with pembrolizumab, also known as KEYTRUDA.
Safety and Efficacy of ADG126
One of the standout pieces of information from the study indicates that ADG126 can be safely administered at a dose of 20 mg/kg every six weeks with an impressive safety profile. Reports noted that less than 20% of patients experienced Grade 3 adverse events, which is a significant achievement in cancer therapy, where toxicity can often limit treatment options.
Overall Response Rate Indicates Promising Outcomes
Significantly, the combination treatment showed a confirmed overall response rate (ORR) of 29% in patients who were diagnosed with microsatellite stable colorectal cancer (MSS CRC). Out of the six patients who responded positively in the 20 mg/kg cohorts, all remain under treatment, with four of those patients continuing for over 40 weeks.
Survival Metrics
Furthermore, patients receiving the 10 mg/kg dosage displayed a median overall survival (OS) of 19.4 months after a follow-up period of 17.8 months. Not only does this figure speak volumes regarding the durability of the response, but it also provides a hopeful outlook for patients impacted by advanced stages of this difficult-to-treat cancer.
Expert Insights and Future Directions
Dr. Marwan Fakih, a noted Professor of Medical Oncology and Therapeutics Research, commented on the findings, emphasizing the reduced treatment-related toxicities associated with the higher dosage. He remarked on the sustained efficacy observed in patients exhibiting responses, suggesting a noteworthy potential for long-term treatment benefits.
Adagene's CEO, Peter Luo, Ph.D., also expressed optimism regarding these results, highlighting the importance of predictive pharmacokinetics and pharmacodynamics in shaping treatment regimens tailored to individual patient needs. This innovative approach offers patients continued access to therapies with minimized side effects, paving the way for enhanced quality of life during their treatment journey.
Patient Cohort Insights
As of the last update, 67 MSS CRC patients, including a subset with peritoneal involvement, have participated in the trial. The doses administered include 10 mg/kg or the tested 20 mg/kg in combination with KEYTRUDA, known for its anti-PD-1 properties. This strategic combination aims to maximize therapeutic effects while carefully observing patient safety as a priority.
Next Steps in Clinical Development
With the continued maturation of data on the 20 mg/kg cohorts, Adagene is eagerly anticipating discussions with regulatory bodies to finalize dosing regimens for forthcoming phases of clinical development. These pivotal conversations will seek to validate the dosing strategies demonstrated to be effective and safe, propelling ADG126 closer to potential market approval.
ASCO Presentation Overview
The exciting data were presented in a poster titled "Safety and Efficacy of ADG126 in Combination with Pembrolizumab: Updated Results of Phase 1b/2 Study in Advanced MSS CRC," during a scheduled viewing at the ASCO Annual Meeting. This event promises to continue highlighting innovative research within the oncology community.
About Adagene and Its Vision
Adagene is a pioneering biotechnology company that integrates advanced computational biology and artificial intelligence to develop novel antibody-drafted cancer therapies aimed at addressing unmet medical needs. Their SAFEbody technology illustrates how personalizing therapies can minimize toxicity while delivering effective treatments.
ADG126, as a non-toxic anti-CTLA-4 SAFEbody specifically targeting regulatory T cells in tumors, encapsulates Adagene’s dedication to providing next-generation immunotherapies for patients battling colorectal cancer among other indications.
Frequently Asked Questions
What is ADG126 and its relevance in cancer treatment?
ADG126 is a novel antibody-based therapy designed to target CTLA-4, enhancing the immune response against cancer cells, particularly in colorectal cancer.
What were the key results presented at ASCO regarding ADG126?
The study presented showed a 29% overall response rate in colorectal cancer patients with a favorable safety profile, indicating potential for significant therapeutic benefit.
What safety measures are associated with ADG126?
ADG126 has demonstrated low incidences of Grade 3 adverse events, showing a promising safety profile compared to traditional cancer therapies.
What is the future direction of the ADG126 clinical trials?
Adagene plans to engage with regulatory authorities to discuss the dosing regimen based on the promising data collected, moving towards further clinical development.
How can patients find more information about Adagene?
Patients and interested parties can visit Adagene's dedicated investor section on their website for up-to-date information on their ongoing clinical trials and innovative therapies.
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