Aanastra Inc Showcases Innovative CAR-T Research at Major Events
Aanastra Inc's Innovative Presentations
Aanastra, a forward-thinking biotechnology company, is set to make significant contributions to the medical science community with multiple preclinical data presentations at important conferences. These presentations will focus on their lead therapeutic programs: anti-CD19 CAR-T (AAN-14x) and the in vivo rescue of P53 mutations in tumors (AAN-53x).
Groundbreaking Data Highlights
The upcoming showcases include promising results such as exceeding 90% B cell depletion within 12 hours of administering a single dose of AAN-14x. Repeated dosages of this treatment have shown no signs of toxicity, affirming its safety profile. AAN-53x has also exhibited remarkable efficacy, with significant tumor regressions across various P53 mutated tumors.
Upcoming Conferences
Aanastra will be presenting their innovative findings at two major events:
Advancing Cell and Gene Therapies for Cancer Conference
Date: October 15-16, 2025
Location: Philadelphia
Poster Title 1: In Vivo CAR-T Generation of Anti-CD19 CAR-T Cells Using CAR mRNA Delivered with PEP-NP Technology
Presenter: Gilles Divita, Ph.D.
Date and Time: October 15, 2025, 5:00 p.m. – 6:30 p.m. ET
Poster Title 2: P53 Mutant Tumor Regression Across P53 Mutations with AAN-53x
Presenter: Gilles Divita, Ph.D.
Date and Time: October 15, 2025, 5:00 p.m. – 6:30 p.m. ET
mRNA Vaccines and Therapeutics Summit
Date: October 23-24, 2025
Location: Barcelona
Oral Presentation Title: A Novel Peptide-Based Nanoparticle Platform for Systemic Targeted Delivery of Therapeutic mRNA
Presenter: Gilles Divita, Ph.D.
Date and Time: October 23, 2025, 4:40 p.m. – 5:20 p.m. CET
P53 Mutations and Their Impact
P53, often referred to as the "Guardian of the Genome," plays a vital role as a tumor suppressor. Its dysfunction can lead to DNA damage accumulation, promoting unchecked cellular growth and cancer. It is estimated that P53 mutations are prevalent in over 50% of all cancers, presenting significant therapeutic challenges. Aanastra aims to address this urgent need through its innovative RNA-based approaches, notably the PEP-NP technology.
The Role of in vivo CAR-T Therapy
Aanastra's in vivo CAR-T therapy champions a more efficient method of T cell engineering within the body. Unlike traditional algorithms which require complex procedures that limit accessibility, this novel approach is designed for broader patient eligibility. The current therapies face limitations like immune responses causing treatment failures. Aanastra's PEP-NP system promises sustained treatment efficacy without such toxicities.
PEP-NP Technology Explained
The foundation of Aanastra's success lies in its proprietary PEP-NP technology. This innovative approach employs short, adaptable peptides that create stable nanoparticles, facilitating the efficient delivery of RNA. By avoiding the use of large proteins and antibodies, PEP-NP enhances the control and precision of targeting various cells and tissues. This non-immunogenic platform makes it a preferred option for delivering vital RNA therapeutics safely.
About Aanastra, Inc.
Aanastra Inc is at the forefront of biotechnological advancements, specializing in RNA therapeutics. By leveraging the targeted PEP-NP platform, Aanastra is redefining the landscape of cancer and genetic disease treatment. Their commitment to precision and safety empowers their innovative pipeline, which includes therapies tailored to immune cells, tumor suppressor genes, and oncogene targeting.
Contacts
For further inquiries, reach out to Aanastra at IR@aanastra.com.
Frequently Asked Questions
What does Aanastra Inc focus on in their research?
Aanastra Inc focuses on developing RNA therapeutics for cancer, autoimmune, and genetic diseases using their innovative PEP-NP technology.
What are the lead programs of Aanastra Inc?
The lead programs are anti-CD19 in vivo CAR-T (AAN-14x) and P53 rescue in tumors (AAN-53x).
Where will Aanastra present its findings?
Aanastra will present at the Advancing Cell and Gene Therapies for Cancer Conference and the mRNA Vaccines and Therapeutics Summit.
Why is P53 significant in cancer biology?
P53 is crucial because it helps regulate cell division and prevents DNA damage, acting as a major tumor suppressor.
What is unique about Aanastra's PEP-NP technology?
PEP-NP technology is unique because it enables targeted delivery of RNA therapeutics without the use of lipids or viral components, enhancing safety and efficacy.
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