Aadi Bioscience Seals Major Deals with New ADC Portfolio and Financing

Aadi Bioscience Seals Major Licensing and Financing Deals

Aadi Bioscience, Inc. (NASDAQ: AADI), a pioneering precision oncology company, has notably advanced its position in the biopharmaceutical sector by entering into exclusive agreements for a promising antibody-drug conjugate (ADC) portfolio. This transformative move is anchored by a $100 million agreement to sell FYARRO® and an additional $100 million in private investment financing (PIPE).

Details of the Exclusive ADC License Agreement

The exclusive license agreement enables Aadi to develop and globally commercialize a three-asset ADC portfolio, created through a collaborative effort with WuXi Biologics and HANGZHOU DAC Biotechnology Co., Ltd. This partnership leverages groundbreaking technology to target key cancer pathways effectively.

Innovative Technology Behind the ADC Portfolio

This three-asset portfolio utilizes advanced linker-payload technology aimed at three critical protein targets: Protein Tyrosine Kinase 7 (PTK7), Mucin-16 (MUC16), and Seizure Related 6 Homolog (SEZ6). With an upfront payment structure totaling $44 million and potential milestone payments reaching up to $540 million, Aadi is strategically positioned to enhance its therapeutic offerings in oncology. The agreement also stipulates royalties on product sales, ensuring sustained revenue potential.

Funding Future Operations through PIPE Financing

To bolster this significant investment into innovative therapies, Aadi is pursuing a PIPE financing deal aimed at raising approximately $100 million in gross proceeds. This comes at a time when the company is actively advancing its preclinical assets, looking to expand its operational runway into late 2028.

Strategic Investment Highlights

The PIPE financing involves selling approximately 21.6 million shares of common stock at a set price of $2.40 per share. This arrangement has attracted substantial interest from several institutional investors, signaling confidence in Aadi's trajectory in the oncology sector. Contributors to this financing include reputable firms like Ally Bridge Group and OrbiMed, highlighting Aadi's robust investor relations.

Emphasis on Advanced Cancer Treatments

David Lennon, Aadi's President and CEO, expressed optimism regarding the new partnership and ADC program, focusing on the imminent need for next-generation cancer treatments. The selected targets within the ADC portfolio are supported by prior evidence indicating their effectiveness in targeting various cancer forms, paving the way for potential improved patient outcomes.

Aadi’s Commitment to Innovation and Leadership

Recently appointed board member, Baiteng Zhao, brings a wealth of experience from his tenure at ProfoundBio, further solidifying Aadi’s leadership in ADC drug development. His previous successes in the industry are expected to be critical as Aadi advances its promising ADC programs.

Future Clinical Development Plans

The ADCs emerging from this partnership are designed with the premise of addressing prevalent cancer types that exhibit significant unmet needs. The intention is to occupy a strong position in the oncology market by maximizing the capabilities of the CPT113 linker platform, which exhibits promising features likely to improve patient treatment experiences.

FYARRO® Sale and Expected Financial Impact

The sale of FYARRO to KAKEN Pharmaceutical for $100 million will enhance Aadi’s financial stability. This product has shown efficacy in treating a specific form of cancer and has generated substantial revenue. Post-sale, KAKEN will inherit the rights and trademark associated with FYARRO, which is expected to enhance its market presence.

Overall Strategic Vision

Aadi Bioscience’s strategic maneuvers reflect its deep commitment to delivering groundbreaking oncology solutions. With the exclusive ADC portfolio and substantial financing secured, the company is more equipped to launch novel therapies that aspire to redefine cancer treatment. The collaborative support from industry leaders like WuXi Biologics and HANGZHOU DAC positions Aadi favorably within the evolving landscape of precision medicine.

Frequently Asked Questions

What is the significance of Aadi's ADC licensing agreement?

The ADC licensing agreement allows Aadi to develop innovative cancer treatments by access to advanced linker-payload technology targeting key cancer markers.

How much funding has Aadi Bioscience secured through PIPE financing?

Aadi has secured approximately $100 million through its PIPE financing deal, aimed at supporting operations and development of its ADC portfolio.

Who are the partners involved in Aadi's ADC development?

Aadi is collaborating with WuXi Biologics and HANGZHOU DAC Biotechnology to innovate and commercialize the ADC portfolio.

What are the anticipated benefits of the ADC portfolio?

The ADC portfolio aims to focus on highly expressed tumor targets, potentially resulting in improved outcomes for patients with various cancer types.

What company is acquiring FYARRO, and for how much?

KAKEN Pharmaceutical is acquiring FYARRO for $100 million, which will bolster Aadi's financial resource for future innovations.

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