Jacobio Pharma Showcases Promising Myelofibrosis Treatment Data

Jacobio Pharma Unveils BET Inhibitor Progress for Myelofibrosis

Jacobio Pharma (1167.HK), a leading clinical-stage oncology company, is making significant advancements in the fight against challenging cancer types with its innovative therapies. Recently, the company shared preliminary Phase I data regarding its BET inhibitor, JAB-8263, designed specifically for the treatment of myelofibrosis (MF). This data was presented at a prominent annual meeting of the American Society of Hematology, catching the attention of healthcare professionals and investors alike.

Initial Findings on JAB-8263

The results presented indicate that JAB-8263 was well tolerated by patients, with a Recommended Phase 2 Dose (RP2D) established at 0.3 mg administered once daily. What stands out in this data is its preliminary efficacy. A substantial number of patients showcased positive outcomes, demonstrating reductions in spleen volume and improvements in their overall symptom scores.

Effective Patient Responses

As of the latest data cutoff, 16 patients suffering from intermediate to high-risk myelofibrosis were enrolled in the study, with 13 patients undergoing efficacy assessments post-treatment. The collective results revealed an impressive mean spleen volume reduction of 19.95% at week 24, with additional patients reporting even higher reductions. Notably:

• Two patients exhibited a spleen volume reduction of 35% or more.
• One patient reached a spleen volume reduction of 34.9%.
• 60% of the patients showed a notable decline of 50% in total symptom scores.
• The best spleen volume responses among patients previously treated with JAK inhibitors were notable, with reductions of 41.2% and 34.9%.
• Half of the evaluated patients achieved significant improvements in their total symptom scores by week 24.

These findings paint an optimistic picture for patients struggling with this challenging blood disorder and demonstrate the potential of JAB-8263 in improving their quality of life.

Future Directions of JAB-8263

The monotherapy expansion study for JAB-8263 is actively ongoing not only within the realm of myelofibrosis but also targeting various solid tumors. Andrea Wang-Gillam, M.D., Ph.D., who serves as the Chief Medical Officer and Global Head of R&D, expressed optimism regarding these developments. She stated that the preliminary data reflects substantial clinical value for this potent BET inhibitor and believes in exploring wider indications for JAB-8263 to ultimately provide breakthrough therapies for a broader range of cancer patients.

The Vision at Jacobio

Jacobio Pharma is dedicated to pioneering new therapies. The company prides itself on its innovative drug development processes, meticulously focusing on six critical signaling pathways: KRAS, immune checkpoints, tumor metabolism, P53, RB, and MYC. The ambition at Jacobio is clear—they aspire for their key projects to rank among the three leading therapies globally. Their vision extends toward becoming a globally recognized leader in drug research and development in partnership with like-minded organizations.

Research and Development Infrastructure

Jacobio maintains R&D centers located in major cities, equipped with cutting-edge technology platforms such as their Induced Allosteric Drug Discovery Platform and their innovative iADC Platform. This integrated approach not only enhances their drug discovery process but also reinforces their commitment to bringing new and effective therapies to the market.

Frequently Asked Questions

What is the focus of Jacobio Pharma?

Jacobio Pharma is focused on developing innovative therapies for oncology, targeting undruggable molecular targets.

What is JAB-8263?

JAB-8263 is a BET inhibitor currently being investigated for its effectiveness in treating myelofibrosis and other cancers.

What were the preliminary findings from the Phase I study?

The preliminary findings indicated that JAB-8263 was well tolerated and showed promising efficacy in terms of spleen volume and symptom reduction for patients with myelofibrosis.

How does Jacobio aim to rank in oncology?

Jacobio aims for its key projects to be among the top three treatments globally, demonstrating their commitment to innovation in drug development.

What is the vision of Jacobio Pharma?

The vision of Jacobio is to become a global leader in drug research and development, recognized for impactful innovations.

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