Synaffix and Qurient Team Up for Groundbreaking ADC Technology
Synaffix B.V., a subsidiary of Lonza, has made headlines by partnering with Qurient Co., Ltd. to enhance the development of antibody-drug conjugates (ADCs). This collaboration focuses on a unique approach to cancer treatment through a dual-payload ADC that combines the strengths of both companies. As industry leaders, they are committed to pushing the envelope of therapeutic innovations, aiming to address significant medical needs in oncology.
About the Licensing Agreement
The licensing agreement allows for the integration of Synaffix's advanced exatecan-based technology and Qurient's CDK7 inhibitor. This combination is designed to offer new hope for patients battling solid tumors, as dual-payload ADCs aim to improve efficacy and reduce resistance associated with traditional cancer therapies. This innovative strategy represents a promising avenue for the future of cancer treatment.
The Technology Behind Dual-Payload ADCs
The new ADC technology promises to deliver not one, but two cytotoxic agents, each with distinct mechanisms of action directed at cancer cells. This strategic design enhances the possibility of overcoming payload resistance that has hindered previous treatments. By targeting multiple pathways, these ADCs could lead to more effective therapies that are gentler on healthy tissues, particularly in challenging cancer cases.
Exclusive Access to Synaffix's Advanced Technologies
Under the terms of the agreement, Qurient gains access to Synaffix's cutting-edge ADC technology platform, which includes key innovations such as GlycoConnect® for antibody conjugation, HydraSpace® polar spacers, and exatecan-based linker-payload technologies. This access is paired with Lonza's extensive industry experience in bioconjugate development and manufacturing, enabling a collaborative effort that combines research, development, and commercialization of this promising ADC.
Manufacturing Collaboration Details
Lonza will take charge of manufacturing the essential components of its proprietary Synaffix technologies. On the other hand, Qurient is tasked with the research, development, and commercialization processes, highlighting a robust partnership aimed at delivering cutting-edge therapies for cancer treatment. This dual-focused collaboration aims not only at technological advancement but also at ensuring that the ADCs reach the clinic efficiently.
Voices of Leadership
Peter van de Sande, the Head of Synaffix, expressed his excitement about the partnership: “This licensing collaboration with Qurient signifies the versatility of our industry-leading ADC platform technology. Enabling the development of a dual-payload ADC built with Synaffix technology reflects our drive to continue pioneering innovation in the field.”
Kiyean Nam, CEO of Qurient, shared his thoughts on the collaboration: “Dual-payload ADCs represent the next frontier in targeted antibody therapeutics, and we look forward to advancing this novel combination of our CDK7 inhibitor and Synaffix's SYNtecan™ linker-payload. The synergy between our technologies is a significant step toward expanding treatment possibilities for patients in need.”
About Synaffix and Its Impact on ADC Development
Synaffix B.V. stands as a key player in the biotechnology landscape, dedicated to advancing the development of ADCs through its clinical-stage, site-specific technology platform. By leveraging advanced technologies, Synaffix empowers companies to create proprietary, best-in-class ADC products. This streamlined approach allows for rapid progression to clinical stages, ensuring that the fight against cancer remains at the forefront of medical innovation.
The Business Model of Synaffix
Synaffix’s business model emphasizes target-specific technology out-licensing, effectively transforming the landscape of ADC development. This strategic focus allows for a robust partner pipeline that continually enhances the potential of ADCs in treating various types of cancers. With a dedication to intellectual property protection through granted patents, Synaffix ensures that its innovations remain at the cutting edge of biotechnology.
Lonza's Role in Advancing Biotech Solutions
Lonza, a renowned organization in the development and manufacturing sector, collaborates across continents to bring groundbreaking therapies to market. With a workforce exceeding 19,000, Lonza partners with pharmaceutical and biotech companies to facilitate the transition from innovative ideas to viable therapies. In the first half of 2025, the company's impressive sales of CHF 3.6 billion underscore its critical role in global healthcare.
About Qurient Co., Ltd. and Its Vision
Qurient Co., Ltd. is on a mission to develop transformative medicines, focusing primarily on oncology and infectious diseases. Headquartered in South Korea, the public clinical-stage biotechnology company has a varied pipeline that includes innovative drugs aimed at addressing high-unmet medical needs. Their commitment to precision and impact positions Qurient as a cutting-edge entity in the fight against some of the most challenging health conditions faced today.
Frequently Asked Questions
What is the significance of the collaboration between Synaffix and Qurient?
The collaboration enables the development of a dual-payload ADC, combining innovative cancer treatment strategies that enhance therapeutic efficacy.
How do dual-payload ADCs function?
Dual-payload ADCs deliver two cytotoxic agents targeting cancer cells through distinct mechanisms, potentially improving treatment outcomes and reducing resistance.
What are the technologies involved in this partnership?
Technologies include Synaffix’s GlycoConnect®, HydraSpace®, and exatecan-based linker-payloads, utilized to enhance ADC efficacy.
What is Lonza’s role in this agreement?
Lonza manufactures the components related to Synaffix's technologies, supporting the overall development and commercialization of the ADC.
What is Qurient's vision in biotechnology?
Qurient focuses on developing innovative therapies to address high-unmet needs in oncology and infectious diseases, advancing solutions for critical healthcare challenges.
