Innovative Breakthroughs from Rapport Therapeutics at AAN 2025

Exciting Presentations at the AAN 2025 Annual Meeting

BOSTON and SAN DIEGO, Rapport Therapeutics, Inc. (NASDAQ: RAPP) is on the brink of showcasing groundbreaking research at the upcoming annual meeting of the American Academy of Neurology (AAN) scheduled from April 5 to April 9, 2025, in San Diego. This clinical-stage biotechnology firm is committed to pioneering small molecule precision medicines for individuals grappling with neurological and psychiatric conditions. The company will conduct repeat poster presentations featuring data initially unveiled at the American Epilepsy Society (AES) meeting.

Focus on RAP-219 in Focal Epilepsy Treatment

Among the materials presented, the spotlight will firmly be placed on RAP-219, a clinical-stage AMPA receptor (AMPAR) negative allosteric modulator currently advancing through Phase 2 clinical trials aimed at treating refractory focal epilepsy. This innovative therapy leverages cutting-edge scientific principles to optimize seizure control.

Highlighting Key Research Findings

Two pivotal posters will be highlighted:

• Poster #002: Optimal Cut Point for Reduction in Long Episode Frequency (Monday, April 7, from 8:00 AM to 9:00 AM PT) - This study utilized receiver operator characteristic (ROC) analysis to determine that a 30% decrease in long episode frequency correlates with a clinically significant reduction (?50%) in overall seizure frequency, irrespective of the initiating antiseizure medication.
• Poster #003: Antiseizure Effects of Selective TARP?8 Negative Allosteric Modulators (Tuesday, April 8, from 11:45 AM to 12:45 PM PT) - The findings suggest that RAP-219 demonstrates powerful, dose-dependent antiseizure effects in preclinical models, particularly when receptor occupancy reaches 70%.

Understanding the Mechanism of RAP-219

RAP-219 represents a significant advancement in targeted therapy. It operates as a negative allosteric modulator specifically designed to influence AMPA receptors by selectively targeting TARP?8. This receptor-associated protein ensures localized action predominantly within the hippocampus and neocortex, where focal seizures frequently initiate. In contrast, its limited expression in other brain regions minimizes potentially severe side effects usually associated with broader-spectrum medications.

Through this precise targeting mechanism, Rapport Therapeutics aims to deliver a treatment approach that distinguishes itself from traditional methodologies. The potential therapeutic applications of RAP-219 extend beyond focal epilepsy, with evaluations underway for conditions such as bipolar disorder and diabetic peripheral neuropathic pain.

Background on Rapport Therapeutics

Rapport Therapeutics is a trailblazer in the biotechnology sector, concentrating on the refinement of small molecule precision medicines tailored for neurological and psychiatric disorders. The innovative foundation established by its founders centers on the role of receptor-associated proteins (RAPs) in brain function, establishing a unique RAP technology platform. This allows Rapport to craft differentiated small molecule candidates that can address significant limitations faced by conventional drug discovery approaches in neurology.

The company's precision neuroscience pipeline prominently features RAP-219, with ongoing assessment as a transformative therapy for refractory focal epilepsy, bipolar mania, and painful neuropathy conditions. Additionally, Rapport Therapeutics is advancing preclinical and discovery-stage initiatives aimed at chronic pain management and hearing disorders.

Frequently Asked Questions

What is the main focus of Rapport Therapeutics at the AAN 2025 Meeting?

Rapport Therapeutics will present significant findings on RAP-219, focusing on its potential correlation with seizure frequency reduction in patients with refractory focal epilepsy.

What are the two primary poster presentations at the meeting?

The two key posters will discuss the optimal cut point for long episode frequency reduction and the antiseizure effects of selective TARP?8 negative allosteric modulators.

What distinguishes RAP-219 from other treatments?

RAP-219 employs a targeted mechanism that specifically influences AMPAR pathways within brain regions, aiming to provide effective treatment with minimized adverse effects.

Which conditions is RAP-219 being evaluated for?

RAP-219 is currently under evaluation for its efficacy in refractory focal epilepsy, bipolar disorder, and diabetic peripheral neuropathic pain.

How does Rapport Therapeutics innovate in drug development?

The company utilizes its unique RAP technology platform, which focuses on receptor-associated proteins to create precision medicines aimed at overcoming challenges in traditional neurology drug discovery.

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