Innovations in Enzymatic Synthesis at TIDES Europe by Codexis

Exciting Advances in Enzymatic Synthesis of RNAi Therapeutics

Codexis, Inc. (NASDAQ: CDXS), renowned for its pioneering enzymatic solutions, is all set to make a significant impact at the TIDES Europe annual meeting. This gathering, taking place in Hamburg, promises to showcase groundbreaking presentations that highlight advancements in RNA interference (RNAi) therapeutic manufacturing. Codexis has chosen this prestigious platform to unveil the real-world applications of its innovative enzymatic synthesis platform.

Showcasing the Enzymatic Synthesis Platform

One of the highlights of Codexis' participation is a joint presentation with Bachem, a leading Contract Development and Manufacturing Organization (CDMO) in siRNA production. The focus will be on demonstrating how Codexis' proprietary double-stranded RNA ligase variants outperform traditional wild-type enzymes. This comparison is set to showcase the potential for enhanced efficiency in siRNA manufacturing, a field that is quickly evolving with the rise of RNA-based therapies.

Presentations That Matter

During the conference, Codexis management will also take part in two oral presentations. The first, dubbed 'TIDES Talk', is scheduled for Wednesday and will delve into the capabilities of Codexis’ RNA Ligase Screening & Optimization Services. Here, they will share insightful data from customer case studies, shedding light on practical outcomes achieved using their enzymatic methods.

Spotlight Presentation: Demonstrating Enzyme Power

The following day, a Spotlight Presentation will further illustrate the versatility of Codexis’ Enzyme Catalyzed Oligonucleotide (ECO) Synthesis™ platform. This session will highlight various techniques, including traditional phosphoramidite chemistry and enzymatic ligation, for developing commercially viable siRNA therapeutics. This public demonstration underscores the platform's flexibility, crucial for meeting the growing demands of RNAi therapy.

Connecting with Codexis at TIDES Europe

Participants of the conference can engage directly with the Codexis team at Booth #709, where they can discuss methods, applications, and learn about the company’s latest innovations. Advance appointments for discussions can be made through their business development team, ensuring meaningful conversations and insights at the event.

Insights on RNAi Therapeutics Manufacturing

The RNA therapeutics landscape has expanded markedly, particularly with the recent rise of messenger RNA (mRNA) vaccines and therapeutics. However, the challenge of scaling up RNAi therapeutic production remains pressing. Traditional methods of chemical synthesis for RNA pose issues regarding nucleic acid quality, quantity, and cost efficiency. The demand for RNAi drugs is anticipated to surpass current production capabilities, highlighting the timeliness of Codexis' advancements in enzymatic synthesis.

Exploring the ECO Synthesis Manufacturing Platform

Codexis' ECO Synthesis™ platform offers a potential solution to these challenges. Designed for scalable production, this innovative platform employs enzymatic processes that could transform the RNAi therapeutic manufacturing landscape. At a recent TIDES USA meeting, Codexis revealed impressive results in synthesizing full-length oligonucleotides, achieving remarkable coupling efficiencies comparable to traditional methods.

Conference Call Details

The Codexis management team will host a conference call to discuss findings from the event, providing further insights into their presentations and product capabilities. For those interested in following the developments, this call will be a valuable opportunity, accessible through dedicated phone lines and webcasts.

About Codexis

As a frontrunner in providing enzymatic solutions, Codexis leverages its patented CodeEvolver technology to develop high-performance enzymes aimed at refining the production processes of pharmaceuticals and nucleic acids. The unique properties of Codexis enzymes facilitate improvements in yield, energy consumption, and overall production efficiency, crucial for advancing the field of RNA therapeutics.

Frequently Asked Questions

What is the role of Codexis at TIDES Europe?

Codexis is showcasing its innovative enzymatic synthesis platform through presentations and a booth where attendees can learn about the latest advancements in RNAi therapeutics.

What is ECO Synthesis™?

ECO Synthesis™ is Codexis' proprietary platform designed for the scalable production of RNAi therapeutics using enzymatic processes.

What kind of data will be presented?

Data will highlight the advantages of Codexis’ double-stranded RNA ligases over wild-type enzymes, demonstrating enhanced manufacturing efficiency for siRNA.

How can attendees engage with Codexis?

Attendees can visit Codexis at Booth #709 and schedule appointments with the business development team for discussions about their innovative solutions.

Is there a conference call scheduled after the event?

Yes, Codexis management will host a conference call to discuss the insights and findings presented at the conference.

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