IMUNON Advances Innovative Ovarian Cancer Treatment at ESMO

IMUNON to Showcase Phase 3 Ovarian Cancer Study at ESMO Congress

IMUNON, Inc. (Nasdaq: IMNN), a prominent figure in clinical-stage biotechnology, recently announced exciting developments regarding its Phase 3 cancer treatment study. The company will be presenting details about the ongoing OVATION 3 clinical trial at the prestigious European Society for Medical Oncology (ESMO) Congress. This international event is set to spotlight groundbreaking cancer therapies, and IMUNON's participation signifies its commitment to advancing treatment methodologies for ovarian cancer.

Overview of the OVATION 3 Trial

The OVATION 3 trial involves IMNN-001, an investigational therapy designed for women diagnosed with advanced ovarian cancer. This revolutionary treatment utilizes IMUNON's proprietary TheraPlas technology platform, which involves an interleukin-12 (IL-12) DNA plasmid vector. This system allows for targeted cell transfection and consistent production of the IL-12 protein directly within the tumor microenvironment, enhancing the body's immune response against cancer cells.

Researchers have demonstrated that IL-12 is crucial for fostering anti-cancer immunity. It induces the proliferation of key immune cells, such as T-lymphocytes, and inhibits mechanisms that allow tumors to evade immune detection. IMNN-001 has shown promising results in clinical settings, offering notable improvements in both progression-free survival and overall survival rates.

Accelerating Patient Recruitment

After initiating patient treatment in July, IMUNON has actively worked to expand the clinical trial by increasing the number of participating sites. Currently, four clinical sites are open for enrollment, with plans for an additional 46 sites to potentially join the study. This aggressive strategy aims to maximize patient engagement and expedite the research process.

Presentation Details at ESMO

At the ESMO Congress, IMUNON will present a poster detailing the Phase 3 OVATION 3 study, which evaluates the safety and effectiveness of combining IMNN-001 with standard chemotherapy treatment regimens. Key aspects of the presentation include:

• Abstract Title: OVATION-3: Phase III trial assessing intraperitoneal IL-12 gene therapy combined with neoadjuvant chemotherapy in patients with advanced epithelial ovarian cancer.
• Presenting Author: Dr. Premal H. Thaker, a respected leader in gynecologic oncology.
• Poster Number: 1234eTiP

Those interested will be able to access the presentation's details through IMUNON's Scientific Presentations webpage after the congress.

Promising Results from Previous Studies

The OVATION 3 study builds on findings from the earlier OVATION 2 trial, which indicated significant survival advantages. The results showed that patients receiving IMNN-001 experienced a median increase of 13 months in overall survival compared to those receiving standard treatment alone. Furthermore, for those on maintenance therapy involving poly ADP-ribose polymerase (PARP) inhibitors, the results were even more pronounced, with a median survival that had not yet been reached.

Understanding Epithelial Ovarian Cancer

Epithelial ovarian cancer presents significant challenges, as it remains one of the most lethal cancers affecting women in the U.S. With about 20,000 new cases each year, many women are diagnosed at advanced stages. The disease is characterized by high recurrence rates, underscoring the urgent need for new therapeutic options that enhance survival rates and reduce recurrence.

Given the complexities of ovarian cancer, targeting the peritoneal cavity where the disease often spreads is vital. Strategies that enhance immune modulation within this environment could represent new frontiers in treatment.

About IMUNON

IMUNON stands at the forefront of clinical-stage biotechnology, pioneering innovative treatments that harness the body’s natural defenses to combat diseases effectively. The company emphasizes its commitment to developing and enhancing its gene delivery technologies, such as TheraPlas and PlaCCine, aimed at creating powerful interventions for various medical conditions.

With ongoing clinical trials, including the OVATION 3 study of IMNN-001 and a first-in-human COVID-19 booster vaccine trial, IMUNON is dedicated to pushing the boundaries of what's possible in modern medicine. Their work, especially in the realm of advanced ovarian cancer treatment, highlights the potential for personalized medicine to change the landscape for patients worldwide.

Frequently Asked Questions

What is the role of IMNN-001 in the OVATION 3 trial?

IMNN-001 is an investigational therapy aimed at treating advanced ovarian cancer by harnessing IL-12's immune-boosting properties.

When is the ESMO Congress taking place?

The ESMO Congress is scheduled for October 17-21, 2025.

What are the expected outcomes of the OVATION 3 study?

The study aims to demonstrate improvements in overall and progression-free survival for patients treated with IMNN-001.

How can patients participate in the OVATION 3 trial?

Patients can enroll through the activated clinical sites currently participating in the study.

Is IMUNON involved in other clinical programs?

Yes, in addition to the OVATION studies, IMUNON is exploring treatments for COVID-19 and other conditions using its innovative platforms.

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