Climb Bio Showcases Promising Developments in Nephrology Research

Overview of Climb Bio's Upcoming Presentations

Climb Bio, Inc. (Nasdaq: CLYM) is set to showcase groundbreaking advancements in nephrology at the prestigious American Society of Nephrology (ASN) Kidney Week. This major event will take place from November 6-9 in Houston, TX, and Climb Bio is eager to present the promising preclinical data for CLYM116, a novel anti-APRIL monoclonal antibody targeting IgA nephropathy (IgAN). In another highlight, the company will share updated data on its innovative budoprutug program focusing on primary membranous nephropathy (pMN).

Promoting Kidney Health with CLYM116

CLYM116 is designed as a highly effective ‘sweeper’ anti-APRIL monoclonal antibody. Preliminary studies have shown that it effectively degrades APRIL, leading to a substantial decrease in IgA levels. This is particularly crucial for patients suffering from IgAN, where high IgA levels significantly contribute to kidney complications. Initial findings from preclinical models indicate that CLYM116 not only enhances antibody recycling but also ensures prolonged and robust reduction of IgA, paving the way for a potential therapeutic breakthrough.

Webcast and R&D Spotlight

On September 29, 2025, Climb Bio hosted an R&D Spotlight webcast centered on CLYM116, during which they reviewed initial preclinical findings and discussed the drug's promising development in the context of IgAN. Such transparent communication showcases the company's commitment to sharing vital information with investors and the medical community alike.

The Budoprutug Program's Clinical Insights

In addition to CLYM116, Climb Bio will introduce long-term follow-up data from its budoprutug clinical trials. Budoprutug is an anti-CD19 monoclonal antibody currently being investigated for its potential in treating various B-cell mediated disorders. The latest data demonstrate long-term control of proteinuria, a key indicator of kidney health, for up to three years in patients treated with budoprutug. Notably, among the participants, some experienced remission without further need for immunosuppressive therapy, indicating a strong potential for disease-modifying effects.

Details on the Clinical Trials

The findings come from a Phase 1b trial that evaluates the safety and efficacy of budoprutug. The results not only reveal the drug's safety profile but also emphasize no clinically significant adverse events throughout the trial. This positive outcome fosters further investigation into budoprutug's role in the therapeutic landscape for pMN and other diseases mediated by B-cells.

Presentation Highlights at ASN Kidney Week

At ASN Kidney Week, Climb Bio will present detailed findings related to both CLYM116 and budoprutug. The poster presentation for CLYM116 is titled "Development and Characterization of CLYM116, a Novel Fc-Engineered Anti-APRIL Monoclonal Antibody with pH-Dependent Binding for IgAN" and is scheduled for November 8, during the pharmacology session.

The second abstract of importance is focused on budoprutug, detailed as "Long-Term Remission of Proteinuria in Primary Membranous Nephropathy After Four Doses of Budoprutug." This illustrates the sustained benefits seen in patient outcomes, reinforcing the drug's potential for managing chronic kidney conditions.

What Sets Climb Bio Apart

Climb Bio stands at the forefront of biotechnology aimed at treating immune-mediated diseases. Their ongoing research with budoprutug and CLYM116 reflects a broader dedication to understanding and alleviating the complexities of autoimmune conditions that impact renal health. Each of their drug candidates showcases a unique mechanism designed to address specific pathways involved in disease progression, ultimately seeking to improve patient quality of life.

Moving forward, Climb Bio continues to be committed to expanding its knowledge and understanding of these serious health conditions. The incorporation of feedback from clinical trials and research will inform its innovative solutions and help tailor treatments that meet patient needs effectively.

Frequently Asked Questions

What is Climb Bio presenting at ASN Kidney Week?

Climb Bio will present preclinical data for CLYM116 and long-term findings for budoprutug related to IgA nephropathy and primary membranous nephropathy.

What is CLYM116?

CLYM116 is a monoclonal antibody developed to target APRIL, aiming to treat IgA nephropathy by significantly reducing IgA levels in patients.

How effective is budoprutug for patients with pMN?

Clinical data suggests that budoprutug controls proteinuria long-term, with some patients achieving remission without additional immunosuppressive treatment.

What is the significance of the ASN Kidney Week presentation?

This presentation provides a platform for Climb Bio to share novel findings with the scientific community and foster collaboration in the nephrology research field.

How can I learn more about Climb Bio's research and pipeline?

For more information on Climb Bio and their developments, please visit their official website.

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