Capstan Therapeutics Unveils Breakthrough Data on CPTX2309
Capstan Therapeutics' Innovative Approach to CAR-T Therapy
Capstan Therapeutics, Inc., a pioneering biotechnology company, is making strides in advanced therapeutic options through innovative RNA delivery systems. At the forefront of their research is CPTX2309, an in vivo chimeric antigen receptor (CAR)-T candidate. This cutting-edge therapy aims to revolutionize the treatment of autoimmune diseases by providing a new mechanism of action that addresses limitations faced by traditional treatments.
Presentation at ACR Convergence 2024
Scheduled to present at the American College of Rheumatology (ACR) Convergence 2024, Capstan will showcase the preclinical data surrounding CPTX2309. This prestigious conference occurs in mid-November, promising to reveal significant findings that demonstrate the potential of this innovative therapy in the field of rheumatology. Attendees can look forward to in-depth discussions and presentations highlighting the efficacy of CPTX2309 in manipulating immune responses to benefit patients suffering from autoimmune conditions.
Details of the Conference Presentation
Capstan's presentation will feature significant insights into the capabilities of CPTX2309, which is engineered to deliver an mRNA payload encoding an anti-CD19 CAR. This approach aims for profound depletion of B cells, a key element in the pathogenesis of various autoimmune diseases. The method is particularly noteworthy for its ability to act without the traditional challenges associated with ex vivo CAR-T therapies.
Highlights of CPTX2309’s Mechanism
Through Capstan's proprietary CellSeeker™ platform, CPTX2309 seeks to reset the immune system, effectively depleting B cells in blood and lymphoid tissues. By utilizing a targeted lipid nanoparticle system, the therapy facilitates a more efficient and effective cellular response compared to conventional CAR-T methodologies. Capstan's Chief Scientific Officer, Dr. Adrian Bot, emphasizes the therapy's aim to induce a durable immune reset that could lead to sustained clinical responses without long-term dependence on drug treatments.
Core Presentation Details
The details surrounding the presentations at ACR are as follows:
- Abstract ID: 0835
- Title: Effective Engineering of CD8+ T Cells from Autoimmune Disease Patients Utilizing a CD8-Targeted Lipid Nanoparticle Encoding an Anti-CD19 CAR mRNA (CPTX2309)
- Presentation Type: Oral presentation
- Presenting Author: Haig Aghajanian, Ph.D., Co-Founder, Head and Vice President of Research at Capstan Therapeutics
- Session: Abstracts: T Cell Biology & Targets in Autoimmune & Inflammatory Disease
- Date and Time: Saturday, November 16, 3:00 PM - 3:15 PM ET
Additionally, Capstan has multiple poster presentations that will further elaborate on the potential of their technology:
- Abstract ID: 0088 - Profound B Cell Depletion and Repopulation with Predominantly Naïve B Cells in Non-Human Primates Achieved Through a Novel In Vivo CD8-Targeted Lipid Nanoparticle mRNA CAR.
- Abstract ID: 0019 - A Novel Product Candidate (CPTX2309) for In Vivo mRNA Engineering of Anti-CD19 CAR T Cells Utilizing Novel CD8-Targeted Lipid Nanoparticles.
Both sessions are scheduled for Saturday, November 16, from 10:30 AM to 12:30 PM ET, promising to provide crucial findings that could reshape therapeutic strategies.
Capstan Therapeutics: A Brief Overview
Capstan Therapeutics is committed to enhancing the health and lives of patients. By utilizing their innovative CellSeeker™ technology, they are paving the way for new solutions to some of the most pressing health challenges. Their mission emphasizes developing targeted in vivo RNA technologies that can alter the landscape of treatment for autoimmune disorders, cancers, and more. As they prepare for their significant presentation at ACR, Capstan exemplifies the future of therapeutic innovations grounded in precision medicine and robust scientific research.
Frequently Asked Questions
What is the significance of CPTX2309?
CPTX2309 represents an innovative in vivo CAR-T therapy that aims to reset the immune system for patients suffering from autoimmune diseases.
When will Capstan present at the ACR conference?
Capstan will present on Saturday, November 16, 2024, with multiple scheduled sessions during the conference.
Who is the presenting author for CPTX2309?
Dr. Haig Aghajanian, Co-Founder and Vice President of Research at Capstan Therapeutics, is the presenting author for CPTX2309.
What are the potential applications of CPTX2309?
CPTX2309 is designed to treat various autoimmune diseases by targeting CD19 positive B cells, which play a critical role in these conditions.
How is Capstan's CellSeeker™ platform unique?
The CellSeeker™ platform utilizes targeted lipid nanoparticles to deliver therapeutic RNA payloads directly to specific cell types, enhancing treatment precision and efficacy.
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