Alithea Genomics Introduces Innovative Full-Length DRUG-Seq Technology
Alithea Genomics Innovates with Full-Length DRUG-Seq Technology
Alithea Genomics has recently announced a significant advancement in RNA sequencing technology with the launch of its MERCURIUS™ Full-Length DRUG-seq library preparation method. This cutting-edge technology is designed to transform the field of transcriptomics and drug discovery by combining massive sample multiplexing, a streamlined extraction-free workflow, and comprehensive transcript coverage in a single RNA-seq approach.
The Power of Full-Length DRUG-seq
Richard Dainese, PhD, the CEO and co-founder of Alithea Genomics, stated, "Full-Length DRUG-seq enables us to detect a wide range of biologically relevant gene features and a significantly higher number of different transcripts and isoforms compared to our existing 3’ mRNA-seq solutions." This innovative approach represents a pivotal milestone for scientists, allowing them to conduct large-scale compound screenings based on full-length RNA sequencing, potentially leading to groundbreaking discoveries in drug development targeting specific gene isoforms.
Key Features of MERCURIUS™ Technology
The MERCURIUS™ Full-Length DRUG-seq technology facilitates the preparation of Illumina-compatible RNA sequencing libraries for as many as 384 samples, offering both time and cost efficiencies. Unlike traditional methods that focus on 3' transcript coverage, the MERCURIUS™ kit provides full-length transcript identification, capable of detecting over 40,000 different transcripts with only 4 million reads per sample. This level of sensitivity rivals that of more costly, non-multiplexed gold standard techniques and allows for the identification of unique isoforms, splicing variants, and alternative promoters.
Future Developments and Market Readiness
Dr. Dainese also revealed that the introduction of Full-Length DRUG-seq is only the beginning. "The availability of Full-Length DRUG-seq is part of a broader strategy to roll out innovative technologies that we will continue to release through 2025. These advancements will consistently harness sample multiplexing and extraction-free processes across an expanding range of sample types and shorter processing times." Currently, Alithea is accepting orders for the MERCURIUS™ Full-Length DRUG-seq kits and associated services, illustrating their commitment to meeting the growing demands of researchers in the field.
Understanding RNA Sequencing
RNA sequencing plays a crucial role in modern biological research by analyzing the quantity and sequences of RNA within a sample using next-generation sequencing (NGS). This technology reveals the genes that are active in a particular cell, providing valuable insights for understanding cellular responses to various drugs and environmental conditions. Such insights can significantly influence the drug discovery and development process, highlighting the importance of robust RNA sequencing techniques like those offered by Alithea.
Alithea's Commitment to RNA Research
Alithea Genomics is dedicated to commercializing advanced library preparation solutions for RNA sequencing. Their innovative technologies are strategically designed to prepare numerous RNA samples in a single tube, which is an attractive alternative to traditional, labor-intensive methods that tend to be costly and time-consuming. Alithea’s BRB-seq (Bulk RNA Barcoding and Sequencing) technology notably reduces the expenses and resources associated with RNA sample preparation, empowering researchers to conduct their work more efficiently and economically.
About Alithea Genomics
Established in 2020 at the EPFL in Lausanne, Switzerland, Alithea Genomics is on a mission to simplify and enhance the generation of substantial RNA data—crucial for the future of research and medication. Their BRB-seq technologies are aimed at enabling researchers to uncover novel biomarkers and gather the essential data needed for developing new drugs, all while significantly decreasing traditional costs and timelines.
Frequently Asked Questions
What is the MERCURIUS™ Full-Length DRUG-seq technology?
The MERCURIUS™ technology is an RNA sequencing library preparation method that allows for massive sample multiplexing and complete transcript coverage, optimizing the drug discovery process.
How does Full-Length DRUG-seq differ from traditional RNA-seq approaches?
Unlike standard RNA-seq, which typically provides 3' coverage, Full-Length DRUG-seq captures full-length transcripts, enabling the detection of a wider range of gene features.
What are the potential applications of Full-Length DRUG-seq?
This technology can be utilized for large-scale drug screening, allowing researchers to identify how drugs affect specific gene isoforms and splicing variants.
Who developed the MERCURIUS™ Full-Length DRUG-seq technology?
Alithea Genomics, a leader in RNA sequencing innovations, developed the MERCURIUS™ technology to advance the field of transcriptomics and drug discovery.
When was Alithea Genomics founded?
Alithea Genomics was founded in May 2020 and is based at the École Polytechnique Fédérale de Lausanne (EPFL) in Switzerland.
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