Ah, I had been working on this and saw your post
--
If kevetrin started showing results in mice at 100mg/kg, then 100mg/kg mouse * 3/37 = 8.108mg/kg for an adult
--
the kg to m^2 conversion for an adult is 60kg/1.6m^2
--
8.108mg/kg*60 /1.6 = 304mg/m^2 (a few dose escalations away eh?)
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I got this math from this link:
http://www.fasebj.org/content/22/3/659.full
|
Species |
Weight (kg) |
BSA (m 2 ) |
K m factor |
|
Human |
|||
|
Adult |
60 |
1.6 |
37 |
|
Child |
20 |
0.8 |
25 |
|
Baboon |
12 |
0.6 |
20 |
|
Dog |
10 |
0.5 |
20 |
|
Monkey |
3 |
0.24 |
12 |
|
Rabbit |
1.8 |
0.15 |
12 |
|
Guinea pig |
0.4 |
0.05 |
8 |
|
Rat |
0.15 |
0.025 |
6 |
|
Hamster |
0.08 |
0.02 |
5 |
|
Mouse |
0.02 |
0.007 |
3 |