TriLink BioTechnologies and Alphazyme Launch Innovative RNA Solution
TriLink BioTechnologies and Alphazyme Collaborate
TriLink BioTechnologies and Alphazyme, both part of Maravai LifeSciences, have united their expertise to introduce CleanScribe RNA Polymerase. This innovative enzyme is designed to significantly reduce double-stranded RNA (dsRNA) during the production of mRNA. By minimizing dsRNA levels by up to 85%, this product aims to facilitate the development of safer and more effective mRNA-based therapeutics.
Understanding CleanScribe RNA Polymerase
CleanScribe RNA Polymerase functions as a DNA-dependent RNA polymerase, enabling in vitro transcription (IVT) of recombinant genes controlled by the T7 promoter. In the traditional IVT process, dsRNA is generated as a byproduct, which can provoke undesirable inflammatory responses in host cells. The CleanScribe polymerase significantly mitigates dsRNA formation compared to the conventional wild-type T7 RNA Polymerase.
Importance of High-Performing Enzymes in mRNA Production
In today’s fast-evolving landscape of mRNA medicine, maintaining a streamlined supply chain is crucial for drug developers. Justin Barbosa, VP and General Manager of TriLink Discovery, emphasizes that integrating high-quality IVT enzymes, mRNA capping analogs, and modified nucleotides are fundamental for efficient mRNA manufacturing. The CleanScribe RNA Polymerase is specifically engineered to provide researchers with a reliable method for reducing dsRNA formation, without compromising other critical mRNA quality factors.
Key Benefits and Applications of CleanScribe RNA Polymerase
The CleanScribe RNA Polymerase offers researchers a robust solution for minimizing dsRNA in their IVT reactions, positioned well for applications such as mRNA synthesis, saRNA synthesis, radiolabeled RNA probe preparation, and RNA construct development for further studies. Its straightforward integration into existing IVT protocols eliminates the need for extensive adjustments, making it accessible for a diverse range of research applications.
Insights from Industry Leaders
Chad Decker, VP and General Manager at Alphazyme, reflects on the collaboration by stating, “We’re excited to work with TriLink on CleanScribe RNA Polymerase. High-quality mRNA therapeutics rely heavily on superior raw materials, so the impacts of this IVT enzyme on the industry are incredibly promising.”
Complementary Offerings from TriLink BioTechnologies
Alongside the CleanScribe RNA Polymerase, TriLink provides a suite of products including mRNA capping analogs, such as the acclaimed CleanCap technology, mRNA raw materials, and various IVT enzymes, including wild-type T7 RNA polymerase. With over 25 years of accumulated expertise in nucleic acids, TriLink is committed to advancing the fields of therapeutics, vaccines, and diagnostics by delivering exceptional technology and chemistry, supported by their CDMO services.
Commitment to Quality and Innovation
TriLink BioTechnologies, as a Maravai LifeSciences entity, aims to be a global leader in nucleic acid and mRNA solutions. The company prides itself on its capacity to deliver high-quality materials and services that support major stakeholders, including pharmaceutical companies and innovative biotechs. The CleanScribe initiative is a reflection of their ongoing commitment to meet the evolving needs of the biotechnology landscape.
Frequently Asked Questions
What is CleanScribe RNA Polymerase?
CleanScribe RNA Polymerase is a novel enzyme developed by TriLink BioTechnologies and Alphazyme that significantly reduces double-stranded RNA in mRNA production.
How does CleanScribe improve mRNA therapeutics?
The enzyme minimizes dsRNA formation by up to 85%, enhancing the safety and efficacy of mRNA-based therapeutics.
Who are the companies involved in this collaboration?
TriLink BioTechnologies and Alphazyme, both part of Maravai LifeSciences, collaborated on this innovative product launch.
What are the applications of CleanScribe RNA Polymerase?
This enzyme is applicable in mRNA synthesis, saRNA synthesis, and preparation of radiolabeled RNA probes, among other uses.
Why is reducing dsRNA important in mRNA production?
Reducing dsRNA is crucial as it can trigger unwanted inflammatory responses during the therapeutic application of mRNA, thus improving its safety profile.
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