Trevi Therapeutics Shares Insights on Cough Relief Research
Insights from Trevi Therapeutics' Recent Cough Relief Study
Trevi Therapeutics, Inc. is making waves in the biopharmaceutical industry with the presentation of its new analyses concerning cough relief times from the Phase 2a CANAL trial. This exciting research will be shared at the upcoming CHEST 2024 conference.
Overview of the CHEST 2024 Presentation
The presentation is set to feature Professor Alyn Morice, a leading figure in respiratory medicine. He will delve into the data collected from patients with idiopathic pulmonary fibrosis (IPF) who received treatment with nalbuphine extended release (ER). The analysis will encompass a cohort of 38 patients, each of whom participated in at least one treatment cycle during the CANAL trial.
Key Findings on Cough Relief
The specifics of the findings are notable. The trial focused on various metrics of cough relief, including the duration of cough-free periods, the total time spent coughing, and the intensity of coughing episodes. Patients treated with nalbuphine ER demonstrated a remarkable increase in the amount of time they remained cough-free, paired with a corresponding decrease in both coughing time and intensity when compared to those receiving placebo treatment.
Safety During the Trial
The safety profile of nalbuphine ER remained consistent with findings from previous trials. Commonly reported treatment-related side effects included gastrointestinal and neurological symptoms, such as nausea, dizziness, and headache. These insights deepen the understanding of the medication's impact on patients.
Significance of the CANAL Trial
This CANAL trial is pivotal as it is one of the first of its kind focusing on treatments for chronic cough in the context of idiopathic pulmonary fibrosis. Chronic cough significantly impacts the quality of life for patients, often leading to social, emotional, and physical challenges. With no current FDA-approved therapies available specifically for chronic cough related to IPF, the potential of nalbuphine ER is a welcome development.
Broader Impact on Chronic Cough Treatment
Beyond its application to patients with IPF, the implications of this research extend to those experiencing refractory chronic cough (RCC). Chronic cough affects more than 10% of the adult population, and the introduction of Haduvio, Trevi’s investigational therapy, aims to address this previously unmet need.
About Trevi Therapeutics, Inc.
Trevi Therapeutics, Inc. is a forefront player in the biopharmaceutical sector, pioneering the development of Haduvio™ (oral nalbuphine ER). This investigational therapy seeks to revolutionize the treatment landscape for chronic cough associated with idiopathic pulmonary fibrosis and refractory chronic cough. Haduvio functions as a dual-receptor modulator, influencing both central brain pathways and peripheral lung responses for a comprehensive therapeutic effect.
Future Directions and Development
As Trevi continues its work, the company is proposing Haduvio as the official trade name for their oral nalbuphine ER product. However, it's important to note that the safety and effectiveness of this investigational drug have yet to be established by any regulatory body.
The unmet medical need in this area cannot be overstated, as chronic cough can worsen disease conditions and significantly elevate the risk of severe health consequences, such as heightened mortality or necessitating a lung transplant. The research showcased at CHEST 2024 is not just a presentation; it is a step towards improving patient outcomes in a landscape where few solutions exist.
Frequently Asked Questions
What is the CANAL trial?
The CANAL trial is a Phase 2a study investigating the effects of nalbuphine ER on cough relief in patients with idiopathic pulmonary fibrosis.
Who is presenting the data at CHEST 2024?
Professor Alyn Morice will present the findings from the CANAL trial.
What are the main findings from the trial?
The trial found that nalbuphine ER significantly increased cough-free periods and reduced overall coughing time and intensity in patients with IPF.
What are common side effects observed in the trial?
Common side effects included nausea, dizziness, anxiety, and headache, which are consistent with prior studies of nalbuphine ER.
Why is this research important?
This research addresses a critical gap in the treatment of chronic cough in IPF and offers hope for improved quality of life for affected patients.
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