Silexion Therapeutics Unveils Promising Phase 2 LODER Data
New Hope in Pancreatic Cancer Treatment with LODER™
Silexion Therapeutics Corp. (NASDAQ: SLXN) has announced groundbreaking findings from its Phase 2 trial of LODER™ for patients afflicted with non-resectable locally advanced pancreatic cancer (LAPC). The recent analysis demonstrates a remarkable objective response rate (ORR) of 56% among patients treated with LODER, and even a 67% ORR for those whose tumors became resectable following treatment. This latest research represents a significant leap in enhancing surgical prospects for pancreatic cancer individuals, particularly for those with KRAS G12D and G12V mutations, which affect around 70% of patients.
Improving Surgical Outcomes with LODER™
Previously reported data indicated that patients who received LODER alongside standard-of-care chemotherapy exhibited an improvement in overall survival by 9.3 months compared to those who only received chemotherapy. The new findings further emphasize the potential of LODER™ not only to treat cancer but also to convert non-resectable tumors into resectable ones, providing new avenues for surgical possibilities for patients experiencing this formidable type of cancer.
Next Generation Innovation with SIL-204
Silexion is advancing its innovative pipeline with SIL-204, a next-generation product engineered to enhance efficacy against an even wider array of KRAS mutations. This breakthrough is anticipated to address pan-G12x and G13D mutations, incorporating unique properties that may enhance stability and delivery to the tumor site, thereby silencing the oncogenic KRAS effectively. These advantages observed in preclinical studies signal a hopeful trajectory for developing treatments for challenging cancers associated with KRAS, such as locally advanced pancreatic cancer.
Insights from Leadership
"We are truly encouraged by these findings, as they showcase LODER's effectiveness in increasing tumor resectability in patients with tough pancreatic cancers," stated Ilan Hadar, Chairman and CEO of Silexion. "As we broaden our pipeline, this data further bolsters our oncogene silencing approach, affirming our commitment to confronting KRAS-driven cancers head-on."
Understanding the Phase 2 Trial of LODER
The open-label Phase 2 trial involved 48 participants from the modified intent-to-treat (mITT) population, specifically those with non-resectable LAPC and borderline resectable pancreatic cancer (BRPC). This trial was carried out across multiple locations and was strategically divided into two cohorts.
Cohort Structure and Patient Involvement
Cohort 1 consisted of 29 patients randomly selected to receive either LODER combined with standard-of-care chemotherapy or chemotherapy alone. This segment’s primary aim was to evaluate overall survival, with 16 participants confirmed to harbor the KRAS G12D/V mutation. In contrast, Cohort 2 enrolled 19 participants who had non-resectable LAPC or BRPC, primarily focusing on assessing the ORR and safety of LODER. Among these patients, seven were confirmed to have KRAS mutations.
About Silexion Therapeutics
Silexion Therapeutics (NASDAQ: SLXN) stands as a pioneering force in developing RNA interference (RNAi) therapies targeting solid tumors fueled by KRAS mutations, recognized as one of the most prevalent oncogenic drivers in malignant cancers today. Their flagship product, LODER, has shown noteworthy outcomes in the Phase 2 trial for non-resectable pancreatic cancer and positions the company as a leader in innovative cancer treatments. Silexion’s commitment to advancing its siRNA candidate, SIL-204, illustrates its vision for tackling a wider spectrum of KRAS mutations. With consistent research and development efforts, Silexion remains dedicated to transforming cancer care, striving for superior outcomes for patients grappling with difficult-to-treat malignancies.
Frequently Asked Questions
What is LODER™ and how does it work?
LODER™ is an innovative therapy developed by Silexion that utilizes RNA interference (RNAi) technology to target and silence KRAS mutations in pancreatic cancer, aiming to improve treatment outcomes.
What were the key results from the Phase 2 trial of LODER?
The Phase 2 trial results indicated a 56% objective response rate for LODER-treated patients, which increased to 67% for those whose tumors became resectable as a result of the treatment.
What is SIL-204?
SIL-204 is Silexion’s next-generation therapeutic candidate designed to target a broader range of KRAS mutations and has shown promising potential in preclinical studies for treating challenging cancers.
How does Silexion aim to improve patient outcomes?
Silexion's approach focuses on developing innovative therapies that specifically target KRAS mutations, with ongoing research aimed at enhancing treatment efficacy and expanding surgical options for patients.
What is the significance of the findings for pancreatic cancer patients?
The findings from the LODER trial signify a crucial advancement in treatment for pancreatic cancer, particularly for patients with previously non-resectable tumors, potentially offering them greater chances for surgical intervention.
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