NextRNA Therapeutics Welcomes Jesse Smith, PhD as CSO
NextRNA Therapeutics Strengthens Leadership with New CSO
NextRNA Therapeutics, a pioneering biotechnology company, has recently expanded its executive team by appointing Jesse Smith, Ph.D., as its Chief Scientific Officer (CSO). This strategic move emphasizes the company’s commitment to tackling long non-coding RNA (lncRNA)-driven diseases. With over two decades of extensive experience in drug discovery and development, Dr. Smith is poised to make significant contributions as NextRNA aims to revolutionize therapies targeting lncRNAs.
Innovative Approach to lncRNA-Driven Diseases
Long non-coding RNAs have emerged as a significant class of therapeutic targets due to their role in recruiting RNA-binding proteins that are critical in the development of various pathological processes. By focusing on disrupting lncRNA-RBP interactions, NextRNA is innovating within the field to develop a new generation of therapeutic agents. The company’s approach positions it uniquely to harness the potential of these molecules in drug development.
Leadership Insights on the Appointment
Dominique Verhelle, Ph.D., the co-founder and CEO of NextRNA, expressed enthusiasm about Dr. Smith's addition to the team. He remarked, "Dr. Smith brings a wealth of expertise in small molecule discovery and is essential in steering our scientific endeavors. With the rising evidence of lncRNAs in the pathogenesis of various diseases, Jesse's role will be critical as we explore new lncRNA targets for the development of impactful medicines. We are excited about the future with Dr. Smith leading our programs in oncology and neuroscience."
Dr. Smith's Vision for NextRNA
Reflecting on his appointment, Dr. Smith shared his excitement about joining NextRNA. He highlighted the company’s commitment to making strides in the emerging lncRNA therapeutic space, stating, "NextRNA’s therapeutic strategy using small molecules to inhibit lncRNAs could cater to various unmet medical needs. I have been highly impressed with the rapid advancement and validation of the company’s proprietary platform, alongside its growing portfolio in oncology and neuroscience. I look forward to furthering our progress and maximizing the potential that lies within NextRNA."
Background of the New CSO
Prior to joining NextRNA, Dr. Smith served as the CSO at Civetta Therapeutics, where he led efforts on drugging Beta Propeller proteins, aiming for therapeutic interventions across various diseases. His exemplary career also includes being the Senior Vice President of Translational Biology at Remix Therapeutics, where he initiated groundbreaking programs in RNA processing. Dr. Smith's tenure in epigenetic drug discovery was particularly notable during his time as Vice President of Biology at Epizyme Pharmaceuticals, where he significantly contributed to developing the first-in-class EZH2 inhibitor and other prominent programs. He holds a Ph.D. in molecular cancer biology and cell biology from Duke University.
About NextRNA Therapeutics
NextRNA Therapeutics stands at the forefront of biotechnology, dedicated to crafting transformative medicines to counteract diseases driven by long non-coding RNAs. With a primary focus on oncology and neuroscience, the company's unique therapeutic strategies aim to disrupt interactions between dysregulated lncRNAs and RNA-binding proteins. This innovative approach not only targets lncRNAs but also allows for potential therapeutic options at the level of RBPs. The united passion of NextRNA’s team reflects a vigorous commitment to advancing pioneering science that leads to meaningful patient outcomes.
Frequently Asked Questions
What is the recent leadership change at NextRNA Therapeutics?
Jesse Smith, Ph.D., has been appointed as the new Chief Scientific Officer at NextRNA Therapeutics, bringing extensive experience in drug discovery.
What therapeutic areas does NextRNA focus on?
NextRNA concentrates on developing medicines for long non-coding RNA-driven diseases, primarily in the fields of oncology and neuroscience.
What is the role of long non-coding RNAs in disease?
lncRNAs play a critical role by recruiting RNA-binding proteins, influencing various pathological processes, and thus, are significant therapeutic targets.
What are small molecules' roles in NextRNA's approach?
NextRNA aims to inhibit the function of lncRNAs with small molecules to disrupt their interactions with RNA-binding proteins, representing an innovative therapeutic strategy.
How does Dr. Smith's experience benefit NextRNA?
Dr. Smith's background in drug discovery and his previous leadership roles will enhance NextRNA's capabilities in advancing its therapeutic programs in oncology and neuroscience.
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