New NIH Grant Unlocks Potential for Cancer Prevention with Lucid Diagnostics

Groundbreaking NIH Grant to Enhance Esophageal Cancer Detection

Lucid Diagnostics Inc. is set to take a major leap in cancer prevention with the recent announcement of an $8 million grant from the National Institutes of Health (NIH). This substantial funding is aimed at supporting a five-year clinical study that focuses on the use of Lucid's advanced testing technologies—EsoCheck and EsoGuard—in at-risk individuals who do not exhibit the typical symptoms of chronic gastroesophageal reflux disease (GERD).

Study Aims and Objectives

The clinical trial, titled "A Clinical Trial of Cancer Prevention by Biomarker Based Detections of Barrett's Esophagus and Its Progression," has an ambitious goal: to assess the effectiveness of these innovative technologies in identifying esophageal precancer, specifically Barrett's Esophagus (BE). This initiative is particularly vital given that patients lacking GERD symptoms often make up a significant portion of esophageal cancer cases.

Target Population and Recruitment

The recruitment plan includes 800 participants who meet the American Gastroenterological Association's risk criteria for screening, sourced from several esteemed research centers including University Hospitals, the University of Colorado, Johns Hopkins University, and the Cleveland Clinic. This diverse cohort will allow the study to draw comprehensive insights into the efficacy of the tests for patients outside of the standard risk criteria.

The Importance of Early Detection

Dr. Amitabh Chak, a leading gastroenterologist involved in the study, highlights a critical truth: nearly half of the prevalent esophageal cancer cases occur in individuals who do not exhibit GERD symptoms. This study seeks to change the current screening paradigms that typically exclude these patients due to existing guidelines that prioritize symptomatic individuals.

"By improving screening accessibility for this overlooked demographic, we aim to significantly enhance cancer detection rates, thereby potentially lowering the mortality associated with esophageal cancer," Dr. Chak explains.

Innovative Tools for Cancer Prevention

Lucid's proprietary technologies, including the EsoCheck Esophageal Cell Collection Device and EsoGuard Esophageal DNA Test, represent a milestone in non-invasive cancer diagnostics. The EsoCheck device collects cell samples, while the EsoGuard test analyzes these samples for genetic markers that indicate precancerous changes. This dual approach enables early intervention strategies that could potentially save lives.

Collaboration and Support from NIH

Lucid Diagnostics expresses enthusiasm about the ongoing collaboration with Drs. Amitabh Chak, Sanford Markowitz, and Joseph Willis—key investigators on the NIH grant. Dr. Lishan Aklog, Lucid's CEO, commented on the potential impact of this study, emphasizing its role in broadening the demographic that can benefit from early detection techniques like EsoGuard.

Future Perspectives for Lucid Diagnostics

As a commercial-stage cancer prevention medical diagnostics firm and subsidiary of PAVmed Inc., Lucid is dedicated to addressing the needs of millions who are at risk of esophageal precancer due to GERD. The EsoGuard test, made available through a non-invasive office procedure, is the first of its kind designed to foster early detection of esophageal cancer, marking a significant advancement in preventive healthcare.

About Lucid Diagnostics and PAVmed Inc.

Lucid Diagnostics continues to innovate in the field of cancer diagnostics, focusing on enhancing patient outcomes through early detection tools. With the backing of PAVmed and the NIH, Lucid sets its sights on a future where esophageal precancer is detected and treated more effectively, potentially saving countless lives.

Frequently Asked Questions

What is the main goal of the NIH grant awarded to Lucid Diagnostics?

The NIH grant aims to support a clinical study evaluating the effectiveness of Lucid's EsoCheck and EsoGuard tests for detecting esophageal precancer in at-risk patients without GERD symptoms.

How many patients will be involved in the study?

The study plans to recruit 800 patients who meet specific risk criteria for screenings.

What are the technologies used in this study?

Lucid Diagnostics will utilize the EsoCheck Esophageal Cell Collection Device and the EsoGuard Esophageal DNA Test for the study.

Why is this study important?

This study is crucial because it aims to identify esophageal precancer in individuals who may not exhibit standard symptoms, addressing a significant gap in current screening practices.

Who are the key investigators involved in the study?

The principal investigators include Dr. Amitabh Chak, Dr. Sanford Markowitz, and Dr. Joseph Willis, who bring expertise from notable institutions.

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