Mabylon AG Secures Funding to Advance ALS and IBD Research
Mabylon AG Secures Significant Research Funding
In a remarkable development, Mabylon AG recently announced that it has secured research grants totaling over CHF 1.3 million. This funding, directed towards innovative treatments for amyotrophic lateral sclerosis (ALS) and inflammatory bowel disease (IBD), is positioning the company at the forefront of biopharmaceutical advancements.
Funding Sources and Goals
The grants have come from notable organizations including Innosuisse Swiss Innovation Agency, Target ALS, and the ALS Association. Specifically, the funding from Target ALS and the ALS Association is aimed at propelling the preclinical development of human-derived TDP-43 intrabodies. These intrabodies seek to restore normal TDP-43 function in ALS patients, effectively reducing harmful TDP-43 aggregates in affected neurons.
Importance of TDP-43 in ALS Research
According to Dr. Kuldip Dave, Senior Vice President of Research at the ALS Association, TDP-43 aggregates are a central feature of ALS, making them a prime target for treatment of both familial and sporadic forms of the disease. The funding will facilitate the progression of Mabylon AG's promising intrabody approach through the Lawrence and Isabel Barnett Drug Development Program, which aims to expedite the journey from laboratory to clinical testing.
Advancements in IBD Treatments
In tandem, Innosuisse has allocated CHF 0.8 million for the development of Mabylon's MY012 program, which focuses on an inflammasome-targeting antibody therapy for inflammatory bowel disease. This program seeks to deliver superior efficacy and safety compared to existing treatments, marking an essential step in addressing serious health challenges associated with IBD.
Innovative Research Approaches
Dr. Niccolò Pengo, the Chief Scientific Officer at Mabylon, emphasized that their research foundation hinges on uncovering naturally occurring antibodies from diverse patient cohorts or immunized animals. This strategy has proven effective in identifying antibody candidates, making their grants a strong validation of the potential impact of Mabylon’s research initiatives.
Future Clinical Development Plans
The excitement within Mabylon AG is palpable, with CEO Alcide Barberis noting gratitude for the financial support that will expedite preclinical proof-of-concept for both the ALS and IBD programs. The strategic goal is to advance these initiatives toward clinical development, potentially in partnership with established biopharmaceutical companies or through dedicated spin-off ventures.
Focus on Allergy Treatments
Interestingly, Mabylon is also actively pursuing the clinical development of an anti-allergen antibody product candidate. They have recently announced progression on a multi-specific anti-allergen antibody aimed at treating peanut allergies, which is currently undergoing Investigative New Drug (IND) studies. A collaboration with Pfizer through the Pfizer Ignite program further underscores their commitment to tackling allergy-related health challenges.
About Mabylon AG
Mabylon is a pioneering Swiss biotechnology firm dedicated to leveraging the therapeutic capabilities of naturally occurring human antibodies. Their focus encompasses the treatment of allergies, neurodegenerative diseases, and inflammatory conditions. The advantages of human-derived antibodies lie in their superior therapeutic potential compared to traditional methods that rely on humanized animal models or artificial libraries.
By capturing antibodies derived from allergic patients, Mabylon enriches the understanding of allergenic epitopes and their implications in disease progression, thus opening avenues for more effective treatments.
Contact Information
Mabylon AG
Wagistrasse 14
8952 Schlieren, Switzerland
Contact:
Alcide Barberis, CEO
Tel: +41 40 88 16 59 64
Frequently Asked Questions
What is Mabylon AG known for?
Mabylon AG is recognized for its innovative work in developing human-derived antibodies to address various health issues, including allergies and neurodegenerative diseases.
What diseases are Mabylon's research grants targeting?
The research grants are specifically focused on advancing treatments for amyotrophic lateral sclerosis (ALS) and inflammatory bowel disease (IBD).
Which organizations provided funding to Mabylon AG?
The funding has been provided by the Innosuisse Swiss Innovation Agency, Target ALS, and the ALS Association.
What is the significance of TDP-43 in ALS research?
TDP-43 aggregates are critical in the pathology of ALS, making them an essential target for potential therapies aimed at improving patient outcomes.
Is Mabylon involved in allergy treatment development?
Yes, Mabylon is actively developing an anti-allergen antibody product for treating peanut allergies and has partnered with Pfizer for this initiative.
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