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Posted On: 11/10/2025 5:49:59 PM
Post# of 158771
Let's get down w/ the science
This was posted to sticktwits today if anyone here wants to see it.
Stage-specific roles of clonally expanded CD8+ T cells in regulating
amyloid pathology in Alzheimer’s disease models
"...Expanded TCR-expressing CD8+ T cells preferentially infiltrate the brain, exacerbating plaque deposition. Moreover, brain-infiltrating CD8+ T cells impair microglial transition into disease-associated states, suppressing amyloid clearance via CCL5-CCR5 signaling. Pharmacological blockade of CCL5 attenuates amyloid deposition, whereas CCL5 administration aggravates pathology. Notably, T cell depletion at later disease stages
exacerbates amyloid pathology, suggesting a temporal shift in their function"...
https://www.nature.com/articles/s41467-025-64503-x
This was posted to sticktwits today if anyone here wants to see it.
Stage-specific roles of clonally expanded CD8+ T cells in regulating
amyloid pathology in Alzheimer’s disease models
"...Expanded TCR-expressing CD8+ T cells preferentially infiltrate the brain, exacerbating plaque deposition. Moreover, brain-infiltrating CD8+ T cells impair microglial transition into disease-associated states, suppressing amyloid clearance via CCL5-CCR5 signaling. Pharmacological blockade of CCL5 attenuates amyloid deposition, whereas CCL5 administration aggravates pathology. Notably, T cell depletion at later disease stages
exacerbates amyloid pathology, suggesting a temporal shift in their function"...
https://www.nature.com/articles/s41467-025-64503-x
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