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Posted On: 11/08/2025 11:52:15 AM
Post# of 158792
This is the blood vessel reduction that My69 is referring to -- from the Pestell, Burger, Lindner paper brentie posted a couple days ago. (Bolding mine.)
[quote]The inhibitory effect of leronlimab on tumor growth, and especially upon metastasis, suggested that another potential mechanism through which leronlimab may exert its antineoplastic effect(s) may be via inhibition of angiogenesis. Quantitative analyses of blood vessels directly feeding into day 10 SW480 colon carcinoma tumors inoculated in the dermis of the flanks revealed a significant decrease in the number of vessels in tumors from leronlimab-treated humanized mice [/quote]
[quote]The inhibitory effect of leronlimab on tumor growth, and especially upon metastasis, suggested that another potential mechanism through which leronlimab may exert its antineoplastic effect(s) may be via inhibition of angiogenesis. Quantitative analyses of blood vessels directly feeding into day 10 SW480 colon carcinoma tumors inoculated in the dermis of the flanks revealed a significant decrease in the number of vessels in tumors from leronlimab-treated humanized mice [/quote]