(Total Views: 654)
Posted On: 11/06/2025 12:51:23 PM
Post# of 158771
The primary outcome listed of the current mCRC trial is ORR
"Efficacy will be measured as the effect on objective response rate (ORR) of leronlimab when used in combination with trifluridine and tipiracil + bevacizumab in patients with CCR5+, refractory, MSS, mCRC.
ORR is defined as the proportion of subjects with the best overall response (BOR) or confirmed CR or confirmed PR according to RECIST version 1.1."
https://clinicaltrials.gov/study/NCT06699836?...study-plan
However, I believe they are measuring the PD-L1 levels throughout which could impact.
"Efficacy will be measured as the effect on objective response rate (ORR) of leronlimab when used in combination with trifluridine and tipiracil + bevacizumab in patients with CCR5+, refractory, MSS, mCRC.
ORR is defined as the proportion of subjects with the best overall response (BOR) or confirmed CR or confirmed PR according to RECIST version 1.1."
https://clinicaltrials.gov/study/NCT06699836?...study-plan
However, I believe they are measuring the PD-L1 levels throughout which could impact.
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