Emulate, Inc. Launches Innovative Chip-R1™ for Drug Testing
Introduction to the Chip-R1™ Rigid Chip from Emulate, Inc.
In a significant advancement for biological modeling, Emulate, Inc. has launched the Chip-R1™ Rigid Chip, which features a unique, minimally drug-absorbing profile. This new product aims to enhance the accuracy of drug testing in areas such as ADME (Absorption, Distribution, Metabolism, and Excretion) and toxicology. By utilizing low-drug-absorbing materials, the Chip-R1 aims to provide researchers with more reliable data on human drug responses.
Key Features of Chip-R1™
Advanced Materials for Enhanced Precision
The Chip-R1 is designed with advanced materials that minimize drug absorption, making it an ideal tool for accurate compound testing. This feature is essential for researchers looking to understand drug behavior in a controlled environment. With the design rooted in the innovative microfluidic framework of Emulate's existing Organ-Chips, scientists can achieve greater control over experimental conditions.
Physiological Relevance in Drug Testing
One of the standout features of the Chip-R1 is its ability to create physiologically relevant shear stress through its modified vascular channel. This is crucial for studies focusing on vascular biology and immune cell interactions. The chip's thinner membrane further enhances cellular communication by allowing for better simulation of in vivo environments.
Enhanced Workflow for Researchers
Beyond its technical specifications, the Chip-R1 improves user experience with a preactivated tissue culture membrane. This allows scientists to streamline their workflow, reducing the time needed to prepare and set up experiments.
Imaging Capabilities and Microscopy Compatibility
The design of the Chip-R1 reduces imaging distance, greatly expanding its compatibility with various microscopy techniques. This enhancement allows scientists to engage in more detailed imaging studies, increasing the value of their research.
Statements from Emulate’s Leadership
According to Danny Levner, PhD, Chief Technology Officer at Emulate, the Chip-R1 marks a transformative step in the Organ-on-a-Chip technology landscape. "This product allows researchers to test compounds that previously posed challenges due to absorption issues," he stated, underscoring the importance of the chip in pharmacokinetics and pharmacodynamics studies, where consistent drug exposure is vital.
Continuing Innovation at Emulate
Lorna Ewart, PhD, Chief Scientific Officer at Emulate, expressed enthusiasm about the Chip-R1's capabilities. She noted that the enhanced detection of hepatotoxicity was a critical advancement compared to the previous Chip-S1® Stretchable Chip. This improvement makes the Organ-Chip tools more accessible to scientists concerned about drug absorption affecting toxicity assessments.
About Emulate, Inc.
Emulate, Inc. is pioneering new pathways in human health with its industry-leading Organ-on-a-Chip technology. This innovative approach provides invaluable insights into human biology, enabling researchers to predict drug responses with unprecedented accuracy. Developed in collaboration with the Wyss Institute for Biologically Inspired Engineering at Harvard University and supported by prominent venture capital firms, Emulate's technology serves a wide spectrum of users across academia, pharmaceuticals, and governmental research sectors.
Frequently Asked Questions
What is the Chip-R1™ Rigid Chip?
The Chip-R1 is a new product from Emulate, designed to minimize drug absorption and enhance biological modeling for drug testing applications.
How does the Chip-R1 improve biological modeling?
It enhances biological modeling by providing a more accurate simulation of the human response to drugs, thanks to its low-drug-absorbing materials and physiologically relevant shear stress design.
What applications can benefit from the Chip-R1?
Studies in pharmacokinetics, pharmacodynamics, and toxicity can all benefit from using Chip-R1, allowing for more accurate predictions of drug behavior.
What makes Chip-R1 different from previous models?
Chip-R1 offers novel features such as a thinner membrane for enhanced cellular crosstalk, better compatibility with microscopy, and improved detection of hepatotoxicity.
Where can I find more information about Emulate and its products?
For more information about Emulate and its innovative Organ-on-a-Chip technology, you can visit their official website.
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