Cambrex Unveils Innovative Peptide Synthesis Technology
Cambrex Unveils Innovative Peptide Synthesis Technology
Cambrex, a prominent player in the contract development and manufacturing organization (CDMO) sector, has made significant strides in peptide synthesis technology. With the recent development of a groundbreaking liquid-phase peptide synthesis (LPPS) technology, Cambrex aims to transform the landscape of peptide manufacturing. Developed by its subsidiary, Snapdragon Chemistry, this advanced technology leverages traditional active pharmaceutical ingredient (API) batch reactors and continuous flow, eliminating reliance on specialized solid-phase reactors and enhancing overall efficiency.
Key Benefits of Liquid-Phase Peptide Synthesis
The innovative LPPS technology brings numerous advantages to the manufacturing process. By dramatically decreasing solvent usage and minimizing the need for excess reagents, this method not only boosts cost-effectiveness but also addresses environmental concerns associated with traditional methods. Dr. Matt Bio, Chief Scientific Officer at Cambrex, highlighted the company's commitment to research and development, stating, "Our new LPPS technology provides a significantly more cost-efficient and environmentally sustainable solution when compared to traditional solid-phase peptide synthesis, substantially reducing solvent usage and allowing the substitution of sustainable solvents."
Scalability and Versatility in Peptide Manufacturing
The versatility of the LPPS technology is evident as it accommodates peptide chains of up to 12 residues in length. For larger peptides, a convergent fragment coupling approach is implemented during the liquid-phase synthesis phase. This adaptable process can be scaled similarly to traditional small molecules, making it an attractive option for a variety of applications in drug development.
Expanding Capabilities in Peptide and Protein Crystallization
In addition to their advancements in LPPS, Cambrex has also pioneered unique technologies in peptide and protein crystallization. This includes a specialized crystallization screening platform designed to discover crystalline forms of peptides and proteins, ultimately enhancing product quality and stability. By reducing the reliance on time-consuming preparative chromatography and lyophilization, Cambrex is reshaping the manufacturing process for complex peptides and proteins.
The Future of Peptide-Based Therapies
With the increasing clinical and commercial success of peptide-based therapies, the need for efficient manufacturing solutions has never been more critical. Thomas Loewald, CEO at Cambrex, emphasized the importance of their innovations, remarking, "It's imperative that we provide industry-leading solutions to develop and scale peptide candidates." This focus on research and development is set to continue, with Cambrex planning further investments in technology developments centered around peptides and exploring artificial intelligence applications for optimizing oligonucleotide processes.
About Snapdragon Chemistry
Snapdragon Chemistry, a subsidiary of Cambrex, is at the forefront of active pharmaceutical ingredient (API) batch and continuous flow process development. Drawing upon cutting-edge automation technology and proprietary equipment, they tackle complex process and analytical development challenges. Based in Waltham, Massachusetts, the team at Snapdragon comprises over 70 skilled employees, including 31 PhD scientists, all dedicated to fostering connections with the local scientific community.
About Cambrex
Cambrex is a global leader in the drug substance development and manufacturing sector. With more than 40 years of expertise, Cambrex provides comprehensive support throughout the entire drug lifecycle, including analytical and IND enabling services. The company boasts a workforce of 2,000 professionals and serves clients across North America and Europe. Their extensive range of specialized drug substance technologies includes continuous flow processes, controlled substances, solid-state science, and material characterization for highly potent APIs.
Frequently Asked Questions
What is liquid-phase peptide synthesis (LPPS)?
LPPS is an innovative technology developed by Cambrex to improve the manufacturing of peptides by reducing solvent usage and enhancing efficiency compared to traditional methods.
Who developed the new LPPS technology?
The LPPS technology was developed by Snapdragon Chemistry, a subsidiary of Cambrex, focusing on improving peptide synthesis processes.
What are the advantages of using LPPS?
LPPS offers cost-efficiency, reduced environmental impact, lower solvent demands, and the capacity to scale similar to traditional small molecule processes.
What does Cambrex specialize in?
Cambrex specializes in contract development and manufacturing services for drug substances, including support across the entire drug lifecycle.
How many employees work at Snapdragon Chemistry?
Snapdragon Chemistry employs over 70 individuals, including 31 PhD scientists, dedicated to advancing pharmaceutical manufacturing technologies.
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