BioRestorative Therapies Showcases ThermoStem® at IFATS 2024
BioRestorative Therapies Unveils Insights at IFATS 2024
BioRestorative Therapies, a pioneer in regenerative medicine, is set to make waves at the upcoming International Federation for Adipose Therapeutics and Science (IFATS) Conference. With a focus on innovative stem cell therapies, BioRestorative aims to demonstrate the exceptional efficacy and tolerability profiles their ThermoStem® platform may provide compared to traditional GLP-1 drugs.
Presentation Overview
At this year's conference, Francisco Silva, the Chief Scientist and Vice President of Research and Development at BioRestorative, will present crucial findings on the therapeutic potential of brown adipose-derived mesenchymal stem cells (BADSCs). The presentation, titled "Brown Adipose Derived Mesenchymal Stem Cells (BADSCs): A Cell-Based Therapeutic Alternative to GLP-1 Agonists for Obesity Treatment," is scheduled for an early morning slot, promising to attract significant attention.
Significant Research Findings
During his presentation, Mr. Silva will highlight the outcomes of peer-reviewed studies conducted using high-fat fed NOD-SCID mice. These studies evaluated the impact of BADSC therapy combined with a BioRestorative-developed 3D Porous Extracellular Matrix-Derived Scaffold. The results showed promising reductions in weight, triglyceride, and blood glucose levels when compared to saline-injected controls. Silva noted the compelling results indicate that the scaffold successfully retains viable cells for over five weeks, showcasing the potential for long-lasting therapeutic effects.
Importance of Brown Fat in Metabolic Health
Mr. Silva is optimistic about the capabilities of their ThermoStem® platform, suggesting that the application of these cell-based therapy candidates may reduce the need for high dosing. Importantly, current GLP-1 obesity medications can lead to 20-40% lean muscle loss during treatment. Contrarily, activating brown fat has demonstrated beneficial outcomes for various organs including the heart, liver, and muscle. The research could redefine how obesity is treated, shifting focus to more sustainable and health-conscious approaches.
New Developments in Obesity Treatment
Recently, BioRestorative announced a significant step forward by revealing a new biologic program focusing on exosomes targeting obesity. The company is advancing towards initiating the formal FDA process for this innovative treatment, aiming to file a Drug Master File (DMF) for their ThermoStem®-based therapy. This initiative represents a proactive commitment to leading the charge in regenerative medicine.
Collaborative Opportunities
In a notable strategic move, BioRestorative has begun discussions with a commercial-stage regenerative medicine company regarding a potential licensing agreement for their allogeneic, off-the-shelf ThermoStem® metabolic intellectual property. While the outcome of these discussions remains uncertain, they signal an exciting opportunity for collaboration within the industry.
About IFATS 2024 Conference
The International Federation for Adipose Therapeutics and Science stands at the forefront of research on adipose biology and related therapies. Since its inception in 2003, IFATS has become a vital platform showcasing innovations in basic and clinical science related to adipose-derived treatments. This year's conference promises to cover a broad spectrum of topics, including regulatory challenges, research advancements, and commercial collaborations in regenerative medicine.
Connecting with BioRestorative Therapies
BioRestorative Therapies' commitment to advancing stem cell technology highlights their role as a significant player in the regenerative medicine landscape. Their research into ThermoStem® therapies exemplifies innovative therapeutic strategies that could transform treatment paradigms for obesity and metabolic disorders.
About BioRestorative Therapies, Inc.
BioRestorative is focused on developing therapeutic products using adult stem cells, with core programs addressing metabolic disorders and disc/spine diseases. Their lead candidate, BRTX-100, utilizes the patient's own stem cells, representing a non-surgical option for those suffering from debilitating disc disorders. Additionally, their metabolic program aims to leverage BADSCs to promote weight loss and mitigate obesity-related health risks.
Frequently Asked Questions
What is the main focus of BioRestorative Therapies at IFATS 2024?
BioRestorative Therapies will focus on showcasing their ThermoStem® platform and its potential advantages over GLP-1 drugs in treating obesity.
Who will present at the conference, and what is his role?
Francisco Silva, the Chief Scientist and Vice President of Research and Development, will present at the conference.
What were the findings from the animal trials using BADSCs?
The trials indicated significant reductions in weight, triglyceride, and blood glucose levels, suggesting the potential for effective cell-based treatments for obesity.
What recent development has BioRestorative announced?
BioRestorative announced a new exosome-based biologic targeting obesity and plans to initiate the FDA approval process.
How does BioRestorative plan to advance their research?
They are engaging with commercial partners to explore licensing agreements for their innovative metabolic therapies.
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