Antengene's XPOVIO® Gains Approval in Thailand for Cancer Treatment
Antengene's Recent Approval of XPOVIO® in Thailand
Antengene Corporation Limited, a renowned global biopharmaceutical company, has achieved a significant milestone with the approval of XPOVIO® (selinexor) by the Thailand Food and Drug Administration. This approval makes XPOVIO® the first and only XPO1 inhibitor sanctioned for commercialization in the market. This therapeutic drug, targeting multiple myeloma (MM), presents a new option for patients that have exhausted previous treatment avenues.
Indications for XPOVIO®
The approved indications for XPOVIO® in Thailand are quite compelling. It will be used in combination with bortezomib and dexamethasone for adult patients who have previously undergone treatment for multiple myeloma. Additionally, it can be utilized in conjunction with dexamethasone for patients who have experienced disease progression after at least four prior therapies. This innovative treatment has already seen approval in several other markets across the APAC region.
Broader Market Impact
Antengene's strategic plan includes the commercialization of XPOVIO® in multiple regions. Already, the drug has been approved for health insurance coverage in countries like China, Australia, Singapore, and South Korea. This broad acceptance signifies the drug's potential impact and effectiveness in treating multiple myeloma, a class of blood cancers characterized by the proliferation of abnormal plasma cells.
Future Aspirations for XPOVIO®
As Antengene continues to expand its reach, plans for launching XPOVIO® in Indonesia are underway, with approval anticipated in the near future. This expansion aligns with the growing demand for innovative cancer therapies in the ASEAN region, where demographic changes are leading to increased healthcare needs.
Innovative Mechanisms of Action
XPOVIO® operates through a unique mechanism by inhibiting the export protein XPO1. This inhibition leads to the accumulation of tumor suppressor proteins within the nucleus of the cancer cells, ultimately reducing tumor growth. Moreover, XPOVIO® can activate glucocorticoid receptors, further enhancing its efficacy in treating specific types of tumors.
About Antengene
Antengene Corporation Limited, listed on SEHK under the ticker 6996.HK, is a leading developer of innovative therapeutics for cancer management. Its emphasis on research and development has positioned it as a pivotal player in the biopharmaceutical landscape. The company's current pipeline includes numerous oncology assets, showcasing a commitment to advancing cancer treatment beyond borders.
Frequently Asked Questions
What is XPOVIO® used for?
XPOVIO® (selinexor) is primarily used for treating adult patients with multiple myeloma, particularly those who have not responded to several other therapies.
How does XPOVIO® work?
XPOVIO® works by inhibiting the XPO1 protein, leading to the accumulation of tumor-suppressive proteins in the nucleus and inducing cell death in cancerous cells.
Where is XPOVIO® approved?
As of now, XPOVIO® is approved in several APAC regions including Thailand, mainland China, Australia, South Korea, and Singapore, among others.
What future plans does Antengene have for XPOVIO®?
Antengene plans to expand the approval of XPOVIO® into additional markets like Indonesia and aims to explore further indications for the drug through various combination regimens.
How can patients access XPOVIO®?
Patients can access XPOVIO® through healthcare providers enrolled in national health insurance schemes and via hospitals that include this treatment in their therapeutic offerings.
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